Association of VNTR Polymorphism of the AS3MT Gene with the Risk of Schizophrenia

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The AS3MT gene encodes arsenic(III) methyltransferase. VNTR polymorphism of the AS3MT gene is characteristic only for the human genome. It is associated with the expression of a human-specific AS3MTd2d3 protein isoform, which is a potential risk factor for the development of schizophrenia. In this study, we for the first time have analyzed the distribution of frequencies of alleles and genotypes of VNTR polymorphism in a large sample of ethnic Russians. The association of VNTR with the risk of schizophrenia has been studied. The study included 1002 patients with schizophrenia and schizophrenia spectrum disorders and 1510 people of the control group. Women with the V3/V3 genotype have an increased risk of schizophrenia (OR = 1.4, 95% CI: 1.11–1.77).

作者简介

G. Korovaitseva

Mental Health Research Centre

编辑信件的主要联系方式.
Email: korovaitseva@mail.ru
Russia, 115522, Moscow

T. Lezheiko

Mental Health Research Centre

Email: golimbet@mail.ru
Russia, 115522, Moscow

I. Oleichik

Mental Health Research Centre

Email: golimbet@mail.ru
Russia, 115522, Moscow

V. Golimbet

Mental Health Research Centre

编辑信件的主要联系方式.
Email: golimbet@mail.ru
Russia, 115522, Moscow

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版权所有 © Г.И. Коровайцева, Т.В. Лежейко, И.В. Олейчик, В.Е. Голимбет, 2023