A systems approach to carcinogenic risk assessment and management for metallurgical workers employed in various blister copper production processes

Vadim I. Adrianovsky; Адриановский Вадим Иннович; E. A. Kuzmina; Кузьмина Е. А.; N. V. Zlygosteva; Злыгостева Н. В.; A. P. Boyarsky; Боярский А. П.; G. Ya. Lipatov; Липатов Г. Я.

doi:10.47470/0016-9900-2017-96-12-1161-1166

A systems approach to carcinogenic risk assessment and management for metallurgical workers employed in various blister copper production processes

Authors: Adrianovsky V.I.¹^,2, Kuzmina E.A.¹, Zlygosteva N.V.¹, Boyarsky A.P.¹, Lipatov G.Y.¹^,2
Affiliations:
1. Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2. Ural State Medical University
Issue: Vol 96, No 12 (2017)
Pages: 1161-1166
Section: OCCUPATIONAL HEALTH
Published: 21.10.2020
URL: https://rjmseer.com/0016-9900/article/view/640713
DOI: https://doi.org/10.47470/0016-9900-2017-96-12-1161-1166
ID: 640713

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Abstract

The paper presents results of the application of the system approach to carcinogenic risk assessment and management based on the identification carcinogens, prediction carcinogenic effects and rationale for targeted preventive and curative measures. Evidence from metallurgical shops where various blister copper production processes are used regardless of the existing smelting technologies shows the risk of cancer to be Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeingeptable even when the working conditions are classified as permissible (class 2) in terms of chemical factors. The highest carcinogenic risk values are observed for occupations with workplaces characterized by a significant release of dust, arsenic being the main risk contributor. In cases of the blast furnace and reverberatory furnace smelting, carcinogenic risks for workers with a 25-year length of employment exceed the permissible level by 17.6 and 28.8 times, respectively, and in the case of bath smelting, carcinogenic risks exceed the permissible level by 5.1 times. The maximum length of employment for bath smelting shop workers amounts to 5.14 years, being by 1.42 and 0.89 years higher than that for the blast furnace and reverberatory furnace smelting shop workers, respectively. The observed cancer mortality rates exceed significantly the expected mortality rates for the tumor of all sites in cases of combined and respiratory cancers. The highest cancer mortality rates were recorded for batch loaders (60%) and smelter (40%) with the highest predicted carcinogenic risk values. Cancer-specific marker levels higher normal ones were detected in 73% of workers from the increased individual carcinogenic risk group. The proposed system approach to carcinogenic risk assessment and management will make it possible to try out components of the risk-based approach in the supervisory activities at industrial facilities with exposure to carcinogens, to establish the acceptable risk levels depending on the length of employment, identify the priority carcinogens; it will also allow indicating a rationale for additional testing for occupational carcinogenesis predictors as part of routine medical examination procedures and to develop preventive measures against key risk factors.

Keywords

carcinogenic risk, arsenic, cancer mortality, systems approach to carcinogenic risk assessment and management, tumor markers

About the authors

Vadim I. Adrianovsky

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing; Ural State Medical University

Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0001-7754-8910

MD, PhD, Senior Researcher of the Epidemiology and Cancer Prevention Laboratory, the Hygiene and Population-Based Disease Prevention Department, Medical Research Center for Prophylaxis and Health Protection of Industrial Workers; Associate Professor, Hygiene and Occupational Diseases Department, Ural State Medical University.

e-mail: adrianovsky@k66.ru

Russian Federation

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