Methodical approaches to the application of genes variations as indices of susceptibility in the health risk assessment

The biological characteristics of the organism, including the genetic status, can be taken as the indices of the individual susceptibility. These susceptibility indices can be applied in the health risk assessment if there is shown the probability of the development of disorders induced by the exposure to environmental factors and if their cause-and-effect relationship with the exposure of these factors is proved. To distinguish the indices values of the individual susceptibility to the health risk formation in conditions of the exposure to the environmental and occupational factors it is proposed to perform consecutive identification of the contingents, risk factors and their probable effects; evaluation of the exposure of risk factors, including the use of exposure markers; genetic testing of the risk contingents; the establishment of a cause-effect relation of the likely effects (responses) with the exposure of these factors; modeling of the dependence of the probable effects (responses) on the exposure of the studied factors for subpopulations with different susceptibility indices; the characteristics of the health risk with an assessment of the additional probability (frequency) of the studied effects (responses) in subpopulation with susceptibility indices. When testing the proposed methodological approaches it was established that it is possible to use the CT gene variation FAS as an index of the individual susceptibility to the development of diseases of the upper respiratory tract with inhalation exposure to vanadium, AG gene variation HTR2A index of the individual susceptibility to the forming of feeding redundancy in peroral exposure to chloroform, CT heterozygote gene variation MTHFR index value of the individual susceptibility to the forming of the pathology of the circulatory system (hypertension) under exposure to the noise. The proposed methodological approaches for the assessment of the individual health risk associated with the exposure to the environmental factors allow more exactly defining the results of the health risk assessment for the individuals with genotype variations that do the conditioning of the excessive individual susceptibility.