Synthesis, study of antitumor activity, and effect of (4-alkoxyphenyl)(3-aryloxy-2-yl)-methanones on tumor DNA in vitro

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Аннотация

Condensation of 1-(4-alkoxyphenyl)ethanones with aromatic aldehydes in the presence of sodium hydroxide in an aqueous-ethanol solution yielded (2E)-3-aryl-1-(4-alkoxyphenyl)prop-2-en-1-ones. Subsequent oxidation of the latter with hydrogen peroxide in a water-ethanol system in a basic medium at room temperature yielded the corresponding epoxy derivatives. The effect of the synthesized compounds on tumor DNA methylation processes in vitro and the antitumor activity of [4-(pentyloxy)phenyl)](3-phenyloxiran-2-yl)methanone in vivo were assessed.

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Авторлар туралы

A. Isakhanyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Хат алмасуға жауапты Автор.
Email: anush.isakhanyan.51@mail.ru
Армения, prosp. Azatutyan, 26, Yerevan, 0014

N. Hakobyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Email: anush.isakhanyan.51@mail.ru
Армения, prosp. Azatutyan, 26, Yerevan, 0014

Z. Hovasyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Email: anush.isakhanyan.51@mail.ru
Армения, prosp. Azatutyan, 26, Yerevan, 0014

S. Dilanyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Email: anush.isakhanyan.51@mail.ru
Армения, prosp. Azatutyan, 26, Yerevan, 0014

L. Nersesyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Email: anush.isakhanyan.51@mail.ru
Армения, prosp. Azatutyan, 26, Yerevan, 0014

А. Aharonyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Email: anush.isakhanyan.51@mail.ru
Армения, prosp. Azatutyan, 26, Yerevan, 0014

I. Danielyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Email: anush.isakhanyan.51@mail.ru
Армения, prosp. Azatutyan, 26, Yerevan, 0014

G. Panosyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Email: anush.isakhanyan.51@mail.ru
Армения, prosp. Azatutyan, 26, Yerevan, 0014

А. Harutyunyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Email: anush.isakhanyan.51@mail.ru
Армения, prosp. Azatutyan, 26, Yerevan, 0014

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