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Synthesis, study of antitumor activity, and effect of (4-alkoxyphenyl)(3-aryloxy-2-yl)-methanones on tumor DNA in vitro
- Authors: Isakhanyan A.U.1, Hakobyan N.Z.1, Hovasyan Z.A.1, Dilanyan S.V.1, Nersesyan L.E.1, Aharonyan А.S.1, Danielyan I.S.1, Panosyan G.А.1, Harutyunyan А.А.1
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Affiliations:
- The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
- Issue: Vol 51, No 3 (2025)
- Pages: 516-522
- Section: ОБЗОРНАЯ СТАТЬЯ
- URL: https://rjmseer.com/0132-3423/article/view/687047
- DOI: https://doi.org/10.31857/S0132342325030139
- EDN: https://elibrary.ru/KRLVUC
- ID: 687047
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Abstract
Condensation of 1-(4-alkoxyphenyl)ethanones with aromatic aldehydes in the presence of sodium hydroxide in an aqueous-ethanol solution yielded (2E)-3-aryl-1-(4-alkoxyphenyl)prop-2-en-1-ones. Subsequent oxidation of the latter with hydrogen peroxide in a water-ethanol system in a basic medium at room temperature yielded the corresponding epoxy derivatives. The effect of the synthesized compounds on tumor DNA methylation processes in vitro and the antitumor activity of [4-(pentyloxy)phenyl)](3-phenyloxiran-2-yl)methanone in vivo were assessed.
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About the authors
A. U. Isakhanyan
The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
Author for correspondence.
Email: anush.isakhanyan.51@mail.ru
Armenia, prosp. Azatutyan, 26, Yerevan, 0014
N. Z. Hakobyan
The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
Email: anush.isakhanyan.51@mail.ru
Armenia, prosp. Azatutyan, 26, Yerevan, 0014
Z. A. Hovasyan
The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
Email: anush.isakhanyan.51@mail.ru
Armenia, prosp. Azatutyan, 26, Yerevan, 0014
S. V. Dilanyan
The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
Email: anush.isakhanyan.51@mail.ru
Armenia, prosp. Azatutyan, 26, Yerevan, 0014
L. E. Nersesyan
The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
Email: anush.isakhanyan.51@mail.ru
Armenia, prosp. Azatutyan, 26, Yerevan, 0014
А. S. Aharonyan
The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
Email: anush.isakhanyan.51@mail.ru
Armenia, prosp. Azatutyan, 26, Yerevan, 0014
I. S. Danielyan
The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
Email: anush.isakhanyan.51@mail.ru
Armenia, prosp. Azatutyan, 26, Yerevan, 0014
G. А. Panosyan
The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
Email: anush.isakhanyan.51@mail.ru
Armenia, prosp. Azatutyan, 26, Yerevan, 0014
А. А. Harutyunyan
The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA
Email: anush.isakhanyan.51@mail.ru
Armenia, prosp. Azatutyan, 26, Yerevan, 0014
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