Synthesis and antibacterial activity of the cyclic 2-substituted thyenopyrimidin-4-ones by bubbling with hydrochloric gas of cycloalkane[b]-2-(n-acylamino)-3-cyanothiophenes

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The reaction of acylation of some 2-amino-3-cyanocycloalkane[ b ]thiophenes with chlorides of various carboxylic acids gave the corresponding cycloalkane[ b ]-2-( N -acylamino)-3-cyanothiophenes, bubbling with hydrochloric gas from an alcoholic solution of amidonitriles to obtain cyclic 2-substituted thienopyrimidin-4-ones. The study of the antibacterial activity of the compounds against gram-positive and gram-negative microorganisms showed that most of them exhibit a weak antibacterial effect against staphylococci.

作者简介

A. Isakhanyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Email: anush.isakhanyan.51@mail.ru

N. Hakobyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

G. Panosyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

A. Harutyunyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

参考

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