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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Medical and Social Expert Evaluation and Rehabilitation</journal-id><journal-title-group><journal-title xml:lang="en">Medical and Social Expert Evaluation and Rehabilitation</journal-title><trans-title-group xml:lang="ru"><trans-title>Медико-социальная экспертиза и реабилитация</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1560-9537</issn><issn publication-format="electronic">2412-2092</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">680937</article-id><article-id pub-id-type="doi">10.17816/MSER680937</article-id><article-id pub-id-type="edn">CQVVML</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Modern approaches to the management of early rehabilitation period after ischemic stroke</article-title><trans-title-group xml:lang="ru"><trans-title>Современные подходы к ведению раннего реабилитационного периода после ишемического инсульта</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4403-0204</contrib-id><contrib-id contrib-id-type="spin">8742-4109</contrib-id><name-alternatives><name xml:lang="en"><surname>Galimov</surname><given-names>Airat R.</given-names></name><name xml:lang="ru"><surname>Галимов</surname><given-names>Айрат Рамирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), Associate Professor</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент</p></bio><email>galimovajrat457@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-8060-8947</contrib-id><name-alternatives><name xml:lang="en"><surname>Stenkina</surname><given-names>Natalya V.</given-names></name><name xml:lang="ru"><surname>Стенькина</surname><given-names>Наталья Владиславовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>beep.boy.official@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-3512-7186</contrib-id><name-alternatives><name xml:lang="en"><surname>Gaikina</surname><given-names>Ekaterina A.</given-names></name><name xml:lang="ru"><surname>Гайкина</surname><given-names>Екатерина Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>kategaikina2002@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-1361-0866</contrib-id><name-alternatives><name xml:lang="en"><surname>Shafikova</surname><given-names>Elvina S.</given-names></name><name xml:lang="ru"><surname>Шафикова</surname><given-names>Эльвина Шагитовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>elvinrose01@icloud.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-3172-7395</contrib-id><name-alternatives><name xml:lang="en"><surname>Bashirova</surname><given-names>Anastasia R.</given-names></name><name xml:lang="ru"><surname>Баширова</surname><given-names>Анастасия Рафаилевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nastena_bashirova@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-2739-1124</contrib-id><name-alternatives><name xml:lang="en"><surname>Yapparov</surname><given-names>Aidar R.</given-names></name><name xml:lang="ru"><surname>Яппаров</surname><given-names>Айдар Ринатович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>aidaripparov40@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-6716-6167</contrib-id><name-alternatives><name xml:lang="en"><surname>Amirkhanyan</surname><given-names>Adel V.</given-names></name><name xml:lang="ru"><surname>Амирханян</surname><given-names>Адель Вагеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>adel.amirkhanyan@bk.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-8202-6762</contrib-id><name-alternatives><name xml:lang="en"><surname>Rozhkov</surname><given-names>Maxim I.</given-names></name><name xml:lang="ru"><surname>Рожков</surname><given-names>Максим Иванович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>maksim.rozhkov.03@bk.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-9285-1970</contrib-id><name-alternatives><name xml:lang="en"><surname>Morozov</surname><given-names>Nikita P.</given-names></name><name xml:lang="ru"><surname>Морозов</surname><given-names>Никита Павлович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>n.morozov82@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-7761-1766</contrib-id><name-alternatives><name xml:lang="en"><surname>Davletbaeva</surname><given-names>Nazgul R.</given-names></name><name xml:lang="ru"><surname>Давлетбаева</surname><given-names>Назгуль Рафаиловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>davletbaeva.2002@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-3984-6591</contrib-id><name-alternatives><name xml:lang="en"><surname>Gimranova</surname><given-names>Nargiza M.</given-names></name><name xml:lang="ru"><surname>Гимранова</surname><given-names>Наргиза Марсовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nargizagimra2001@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-6668-2261</contrib-id><name-alternatives><name xml:lang="en"><surname>Yamgurova</surname><given-names>Rosalia R.</given-names></name><name xml:lang="ru"><surname>Ямгурова</surname><given-names>Розалия Разитовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>rozalia.yamgurova02@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-0574-0833</contrib-id><name-alternatives><name xml:lang="en"><surname>Shagiakhmetova</surname><given-names>Dilbar R.</given-names></name><name xml:lang="ru"><surname>Шагиахметова</surname><given-names>Дильбар Рустамовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>shagiahmetovadilbar@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-9619-0869</contrib-id><name-alternatives><name xml:lang="en"><surname>Sultanmuratov</surname><given-names>Ildar R.</given-names></name><name xml:lang="ru"><surname>Султанмуратов</surname><given-names>Ильдар Равилович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>avya_vyayv_14@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-7550-6000</contrib-id><name-alternatives><name xml:lang="en"><surname>Reshetnikova</surname><given-names>Anastasia A.</given-names></name><name xml:lang="ru"><surname>Решетникова</surname><given-names>Анастасия Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>anastasia63372@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Bashkir State Medical University</institution></aff><aff><institution xml:lang="ru">Башкирский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Ulyanovsk State University</institution></aff><aff><institution xml:lang="ru">Ульяновский государственный университет</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</institution></aff><aff><institution xml:lang="ru">Воронежский государственный медицинский университет им. Н.Н. Бурденко</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-07-16" publication-format="electronic"><day>16</day><month>07</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-12-09" publication-format="electronic"><day>09</day><month>12</month><year>2025</year></pub-date><volume>28</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>99</fpage><lpage>112</lpage><history><date date-type="received" iso-8601-date="2025-05-29"><day>29</day><month>05</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-07-07"><day>07</day><month>07</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2028-12-09"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://rjmseer.com/1560-9537/article/view/680937">https://rjmseer.com/1560-9537/article/view/680937</self-uri><abstract xml:lang="en"><p>Ischemic stroke is a form of acute cerebrovascular accident in which the underlying pathogenesis is an occlusion of the head or neck arteries supplying the brain, leading to ischemia and, consequently, to the death of cortical areas and the development of focal neurological deficits. This condition remains one of the leading causes of mortality and disability worldwide. According to recent statistics, approximately 16.9 million new cases of ischemic stroke are reported annually, and this figure continues to grow, particularly due to the increasing life expectancy of the population. This review analyzes modern approaches to managing the early rehabilitation period after ischemic stroke. The authors examine the pathophysiological foundations of the early recovery period, including the role of neuroplasticity, neuroinflammation, and interhemispheric cortical reorganization. Special attention is paid to innovative rehabilitation methods such as robotic technologies, transcranial magnetic stimulation, virtual reality, and cell therapy. The review evaluates the effectiveness of these methods based on randomized controlled trials and meta-analyses. The results demonstrate significant improvements in functional outcomes with the early initiation of rehabilitation programs and the combined use of traditional and innovative techniques.</p></abstract><trans-abstract xml:lang="ru"><p>Ишемический инсульт (ИИ) — это одна из форм острого нарушения мозгового кровообращения (ОНМК), в основе патогенеза которого лежит окклюзия артерий головы или шеи, кровоснабжающих мозг, приводящая к ишемии и, как следствие, к гибели участков коры мозга и развитию очаговых неврологических нарушений. Данное заболевание остаётся одной из ведущих причин смертности и инвалидности в мире. Согласно последним статистическим данным, ежегодно регистрируется около 16,9 млн случаев ИИ, и данный показатель неуклонно растёт, особенно в связи с увеличением продолжительности жизни населения. Настоящий обзор посвящён анализу современных подходов к ведению раннего реабилитационного периода после ИИ. Авторами проанализированы патофизиологические основы раннего восстановительного периода, включая роль нейропластичности, нейровоспаления и межполушарной реорганизации коры. Особое внимание уделено инновационным методам реабилитации, таким как роботизированные технологии, транскраниальная магнитная стимуляция, виртуальная реальность и клеточная терапия. Проведён обзор эффективности данных методов на основе данных рандомизированных контролируемых исследований и метаанализов. Результаты демонстрируют значительное улучшение функциональных исходов при раннем начале реабилитационных программ и комбинированном применении традиционных и инновационных методик.</p></trans-abstract><kwd-group xml:lang="en"><kwd>ischemic stroke</kwd><kwd>neurorehabilitation</kwd><kwd>restorative medicine</kwd><kwd>digital technologies</kwd><kwd>neuroplasticity</kwd><kwd>telemedicine</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ишемический инсульт</kwd><kwd>нейрореабилитация</kwd><kwd>восстановительная медицина</kwd><kwd>цифровые технологии</kwd><kwd>нейропластичность</kwd><kwd>телемедицина</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Kastey RM, Dyusembekov EK, Zetov ASh, et al. Epidemiological aspects and factors of acute cerebrovascular accidents (literature review). Vestnik Kazakhskogo Natsional’nogo Meditsinskogo Universiteta. 2020;(2–1):591–596. 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