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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Medical and Social Expert Evaluation and Rehabilitation</journal-id><journal-title-group><journal-title xml:lang="en">Medical and Social Expert Evaluation and Rehabilitation</journal-title><trans-title-group xml:lang="ru"><trans-title>Медико-социальная экспертиза и реабилитация</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1560-9537</issn><issn publication-format="electronic">2412-2092</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">688638</article-id><article-id pub-id-type="doi">10.17816/MSER688638</article-id><article-id pub-id-type="edn">OGLKCZ</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original study articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Sedentary lifestyle as a risk factor for domains of individual vitality in women</article-title><trans-title-group xml:lang="ru"><trans-title>Гиподинамия как фактор риска для доменов индивидуальной жизнеспособности женщин</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7546-6679</contrib-id><contrib-id contrib-id-type="spin">9933-5015</contrib-id><name-alternatives><name xml:lang="en"><surname>Kochetkova</surname><given-names>Irina V.</given-names></name><name xml:lang="ru"><surname>Кочеткова</surname><given-names>Ирина Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), Assistant Professor</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент</p></bio><email>iri4217@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</institution></aff><aff><institution xml:lang="ru">Воронежский государственный медицинский университет им. Н.Н. Бурденко</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-11-13" publication-format="electronic"><day>13</day><month>11</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-12-20" publication-format="electronic"><day>20</day><month>12</month><year>2025</year></pub-date><volume>28</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>127</fpage><lpage>136</lpage><history><date date-type="received" iso-8601-date="2025-08-04"><day>04</day><month>08</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-10-30"><day>30</day><month>10</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2029-01-26"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://eco-vector.com/for_authors.php#07</ali:license_ref></license></permissions><self-uri xlink:href="https://rjmseer.com/1560-9537/article/view/688638">https://rjmseer.com/1560-9537/article/view/688638</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND: </bold>Sedentary lifestyle, increasingly prevalent in the modern technological environment, poses a threat to female vitality. It leads to physiological alterations including muscle weakening, impaired cardiac function, metabolic dysregulation, and hormonal imbalance, contributing to chronic disease development. Sedentary behavior also adversely affects psychoemotional functioning, causing depression, anxiety, cognitive decline, and social isolation, thereby reducing women’s quality of life.</p> <p><bold>AIM:</bold><bold> </bold>This study aimed to evaluate examination data of women aged 60 years using a domain-based approach in the presence of sedentary lifestyle.</p> <p><bold>METHODS:</bold> The study was conducted in a Medical Prevention Department. The somatic, locomotor, sensory, cognitive, psychological, and nutritional domains were assessed. The following methods were used: Cardiovisor, echocardiography, heart rate variability analysis, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, glycated hemoglobin, C-reactive protein, omega-3 fatty acids, dynamometry, bioimpedancemetry, ophthalmologic examination, FRAIL scale, MNA scale, MMSE, Katz Index, Beck Depression Inventory, and Asthenic State Scale. Data were analyzed using StatTech version 4.8.0.</p> <p><bold>RESULTS: </bold>Presarcopenia was identified in 32.7% of women with sedentary lifestyle (18 of 55), whereas no cases were recorded among physically active women (0%). Sedentary behavior was observed in 94.5% of patients with type 2 diabetes (52 of 55), whereas all women without diabetes (45 of 45; 100%) demonstrated adequate physical activity (<italic>p</italic> &lt; 0.001). Age-related cognitive decline was detected in 50.9% of sedentary participants (28 of 55), whereas no such cases occurred in the active group (0%; <italic>p</italic> &lt; 0.001). Asthenic syndrome was present in all 55 sedentary women (100%), and was absent in the active group (45; <italic>p</italic> &lt; 0.001). Quality-of-life score in sedentary women was 0.98 (interquartile range 0.92–1.04), indicating statistically significant differences (<italic>p</italic> &lt; 0.001). Women with insufficient physical activity had significantly higher serum neutral lipid levels, 3.71 ± 0.35 vs 2.68 ± 0.28 in physically active women (<italic>p</italic> &lt; 0.001).</p> <p><bold>CONCLUSION: </bold>Sedentary lifestyle adversely affects the physical and emotional well-being of women, as well as their social participation. Addressing this issue requires educational programs, accessible environments for physical activity, and promotion of healthy lifestyle habits. Investment in overcoming sedentary lifestyle is essential for improving women’s lives and supporting their contribution to societal development.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> Гиподинамия, распространённая в современном мире из-за развития технологий, представляет угрозу для женской жизнеспособности. Она вызывает физиологические изменения, такие как ослабление мышц, ухудшение работы сердца, нарушение метаболизма и гормональный дисбаланс, приводя к хроническим заболеваниям. Гиподинамия негативно влияет на психоэмоциональное состояние, вызывая депрессию, тревогу, снижение когнитивных функций и социальную отчуждённость, что ухудшает качество жизни женщин.</p> <p><bold>Цель. </bold>Оценка данных обследования пациенток 60 лет с учётом доменного подхода при наличии гиподинамии.</p> <p><bold>Методы.</bold> Исследование проводилось в отделении медицинской профилактики. Анализировались параметры соматического статуса, локомоторной, сенсорной, когнитивной, психологической и нутритивной сфер. Использовались следующие методы: «Кардиовизор», эхокардиография, анализ вариабельности сердечного ритма, определение соотношения нейтрофилов и лимфоцитов, соотношения тромбоцитов и лимфоцитов, гликированного гемоглобина, С-реактивного белка, омега-3 жирных кислот, динамометрия, биоимпедансометрия, офтальмологическое обследование, шкалы FRAIL, MNA, MMSE, шкала Катца, шкала Бека и шкала астенического состояния. Данные обработаны с помощью StatTech 4.8.0.</p> <p><bold>Результаты.</bold> Предсаркопения обнаружена у 32,7% пациенток, ведущих малоподвижный образ жизни (18 из 55), в то время как в группе с активным образом жизни подобные случаи не регистрировались (0%). У 94,5% пациенток с сахарным диабетом 2 типа (52 из 55) была отмечена гиподинамия, тогда как в группе без диабета все 45 участниц (100%) демонстрировали достаточную физическую активность (<italic>p</italic> &lt; 0,001). Возрастное снижение когнитивных функций отмечено у 50,9% пациенток с гиподинамией (28 из 55), в то время как в группе с активным образом жизни подобные случаи отсутствовали — 0% (<italic>p</italic> &lt; 0,001). Астенический синдром проявлялся у всех 55 пациенток с гиподинамией (100%), тогда как в группе с активным образом жизни (45 человек) данное состояние не наблюдалось ни у кого — 0% (<italic>p</italic> &lt; 0,001). Показатель качества жизни у лиц с гиподинамией составил 0,98 (интерквартильный размах: 0,92–1,04), что свидетельствует о статистически значимых различиях (<italic>p</italic> &lt; 0,001). У лиц, не проявляющих достаточной физической активности, зафиксирован значимо более высокий уровень нейтральных липидов в сыворотке крови — 3,71 ± 0,35 по сравнению с теми, кто ведёт активный образ жизни — 2,68 ± 0,28 (<italic>p</italic> &lt; 0,001).</p> <p><bold>Заключение. </bold>Малоподвижный образ жизни вредит физическому и эмоциональному благополучию женщин, а также их социальной активности. Для решения этой проблемы необходимы просветительские программы, доступная среда для физических упражнений и поощрение здоровых привычек. Инвестиции в преодоление гиподинамии важны для улучшения жизни женщин и их участия в развитии общества.</p></trans-abstract><kwd-group xml:lang="en"><kwd>age-associated diseases</kwd><kwd>risk factors</kwd><kwd>women</kwd><kwd>sedentary lifestyle</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>возраст-ассоциированные заболевания</kwd><kwd>факторы риска</kwd><kwd>женщины</kwd><kwd>гиподинамия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Timofeeva AA, Vedenina OA. Hypodynamia as a Problem of Modern Students. In: Physical Culture, Sports, and Health of Student Youth in Modern Conditions: Problems and Prospects of Development: Materials of the Regional Student Scientific and Practical Conference, April 7, 2021, Yekaterinburg. Yekaterinburg: RGPPU; 2021:226–230. (In Russ.)</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Guseva OV. 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