Machine Learning for Diagnosis of Diseases with Complete Gene Expression Profile

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Abstract

This paper considers the use of machine learning for diagnosis of diseases that is based on the analysis of a complete gene expression profile. This distinguishes our study from other approaches that require a preliminary step of finding a limited number of relevant genes (tens or hundreds of genes). We conducted experiments with complete genetic expression profiles (20 531 genes) that we obtained after processing transcriptomes of 801 patients with known oncologic diagnoses (oncology of the lung, kidneys, breast, prostate, and colon). Using the indextron (instant learning index system) for a new purpose, i.e., for complete expression profile processing, provided diagnostic accuracy that is 99.75% in agreement with the results of histological verification.

About the authors

A. M. Mikhaylov

Trapeznikov Institute of Control Sciences, Russian Academy of Sciences

Email: alxmikh@gmail.com
Moscow, Russia

M. F. Karavay

Trapeznikov Institute of Control Sciences, Russian Academy of Sciences

Email: mkaravay@yandex.ru
Moscow, Russia

V. A. Sivtsov

Trapeznikov Institute of Control Sciences, Russian Academy of Sciences

Email: thedege@yandex.ru
Moscow, Russia

M. A. Kurnikova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology

Author for correspondence.
Email: mish2109@yandex.ru
Moscow, Russia

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