Biological age as a method for estimating health level under environmental risks (literature review)

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Abstract

The widespread formation of unfavorable environmental, the swiftness of modern life with large information and psycho-emotional loads and extremely natural and climatic cataclysms, as well as harmful addictions and wrong way of life of modern human, lead to the development of stress and disruption of the mechanisms of adaptation of the human body and its accelerated wear. This stimulates the development of research on the creation of new methods of integrated assessment of health and quantitative assessment of the aging processes of the body systems and the whole body, as well as the possibilities of new methods of risk assessment of climatic and environmentally related pathological and age-related diseases. The aim of the work was to consider the methodology of quantitative assessment of individual health and the rate of aging of the human body on the basis of the system index of Biological age (BA); description of its essence and structure, requirements for tests - biomarkers of aging used as the index of BA, definition of possibilities and scope of application of the BA method in modern practice of Biomedicine. The use of modern methods of scientific analysis - a systematic approach to the analysis of the processes of human aging and determine its quantitative side - the value of BA, allows a reasonable approach to the choice of the number of BM, to take into account their information content and precision, and the cost of diagnostics and availability for different users, to take into account the specific objectives of the researcher. The use of the index-partial BA allows individual approaching the choice of biomarkers and create personalized panels for the definition of BA programs for the prevention of aging in personalized preventive medicine. The complexity of the content and calculation of indices of BA requires automation and the use of methods of modern computer science and computer calculations and programs. For this purpose, we have created special computer software for diagnosing aging by calculating the BA indices with the possibility of choosing BM and automatic calculation of indicators and conclusions.

About the authors

N. I. Prokhorov

I.M. Sechenov First Moscow State Medical University

Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0002-4510-2890
Russian Federation

V. I. Dontsov

Federal Research Center “Computer Science and Control”

Email: noemail@neicon.ru
ORCID iD: 0000-0002-2234-4715
Russian Federation

Vyacheslav N. Krutko

I.M. Sechenov First Moscow State Medical University; Federal Research Center “Computer Science and Control”

Email: krutkovn@mail.ru
ORCID iD: 0000-0002-2779-8775

MD, Ph.D., Head of Laboratory, Federal Research Center “Computer Science and Control”, Moscow, 119333, Russian Federation.

e-mail: krutkovn@mail.ru

Russian Federation

T. M. Khodykina

I.M. Sechenov First Moscow State Medical University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-9646-5595
Russian Federation

References

  1. Zajceva N.V., Ulanova T.S., Nurislamova T.V., Popova N.A., Mal’ceva O.A. Quantitative indicators of nitrates in urine and n-nitrosodimethylamine in blood as markers of oral exposure of nitrates coming from drinking water. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2018; 97(11): 1087-92. (in Russian). https://doi.org/10.18821/0016-9900-2018-97-11-1087-92
  2. Malov A.M., Lukovnikova L.V., Alikbaeva L.A., Jakubova I.Sh., Shhegolihin D.K. Results of biomonitoring of mercury pollution within the metropolis. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2018; 97(12): 1189-94. (in Russian). https://doi.org/10.18821/0016-9900-2018-97-12-1189-1194
  3. Jashhenko S.G., Rybalko S.Ju., Shibanov S.Je., Grigor’ev O.A. Electromagnetic environment of radio frequency range of mobile communication and morbidity of adult population with diseases of the circulatory system. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2018; 97(12): 1184-8. (in Russian). https://doi.org/10.18821/0016-9900-2018-97-12-1184-1188
  4. Krijt V.E., Sladkova Ju.N., Smirnov V.V.Hygiene and sanitation. Two-level road bridges as a special source of noise impact on residential development on the example of the Kanonersky island of St. Petersburg. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2018; 97(12): 1162-5. (in Russian). https://doi.org/10.18821/0016-9900-2018-97-12-1162-1165
  5. Malysheva A.G., Shelepova O.V., Vodjanova M.A., Doner’jan L.G., Ushakova O.V., Judin S.M. Ekologo-hygienic problems of application of antihydrogen reagents in the conditions of a large megapolis (on the example of the city of Moscow). Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2018; 97(11): 1032-7. (in Russian). https://doi.org/10.18821/0016-9900-2018-97-11-1032-37
  6. Saltykova M.M., Bobrovnickij I.P., Jakovlev M.Ju., Banchenko A.D., Nagornev S.N. A new approach to the analysis of the influence of weather conditions on the human body. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2018; 97(11): 1038-42. (in Russian). https://doi.org/10.18821/0016-9900-2018-97-11-1038-42
  7. Bol’shakov A.M., Krut’ko V.N., Kutepov E.N., Mamikonova O.A., Potemkina N.S., Rozenblit S.I. et al. Chunks of Information overload as a new topical section of hygiene of children and adolescents. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2016; 95(2): 172-7. (in Russian). https://doi.org/10.18821/0016-9900-2016-95-2-172-177
  8. Ermakova N.A., Mel’nichenko P.I., Prohorov N.I., Timoshenko K.T., Matveev A.A., Kochina E.V. et al. Lifestyle and health of students. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2016; 95(6): 558-63. (in Russian). https://doi.org/10.18821/0016-9900-2016-95-6-558-563
  9. Smirnova T.M., Krut’ko V.N. Historical dynamics of mortality and its accounting for the strategic planning of medical and social care for the elderly. Klinicheskaja gerontologija. 2018; 24(9-10): 63-5. (in Russian).
  10. Bol’shakov A.M., Krut’ko V.N., Smirnova T.M., Chankov S.V. Method of ranking indices and its use for comparative analysis of hygienic welfare of the population. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2016: 95(3): 306-11. (in Russian). https://doi.org/10.18821/00169900-2016-95-3-306-311
  11. Vlasova I.A. Nonspecific Reactions of adaptation and functional state of the organism elderly. Sibirskiy meditsinskiy jurnal (Irkutsk). 2012; 113(6): 46-8. (in Russian).
  12. Mel’nichenko P.I., Ermakova N.A., Prohorov N.I., Matveev A.A., Kochina E.V. Biological age as a rating criterion and the state of health of students. Zdorov’e naselenija i sreda obitanija. 2017; 2(287): 15-7. (in Russian).
  13. Krutko V.N., Dontsov V.I., Mamikonova O.A., Markova A.M., Molodchenkov A.I., Potemkina N.S. et al. Intelligent internet technology for personalized health-saving support. Advances in Intelligent Systems and Computing. 2018; 658: 157-65. https://doi.org/10.1007/978-3-319-67349-3_14
  14. Smirnova T.M., Krut’ko V.N., Markova A.M. Analysis of biologocal age using a computer to monitor the health and psycho-emotional condition as an element of a preventive and personalized approach to health management. Vestnik vosstanovitel’noj mediciny. 2018; 1(83): 54-60. (in Russian).
  15. Bashkireva A.S. Assessment of accelerated aging truck drivers on the model of biological age on physical performance indicators. Uspekhi gerontologii. 2012; 25(4): 709-17. (in Russian).
  16. Puchkova E.I., Alishev N.V. Indicators of biological age and ageing in liquidators of consequences of radiation accidents]. Uspeki gerontologii. 2011; 24(1): 99-104. (in Russian).
  17. Cheremisinova I.I., Davydov N.O., Grivko N.V., Barysheva Y.S. Monitoring of biological age of the students as an indicator of adaptation in University. Vrach-aspirant. 2012; 53(4): 285-92. (in Russian).
  18. Bol’shakov A.M., Krut’ko V.N., Dontsov V.I. Possibilities of computer systems for assessment of prenosological changes in health. Gigiena i sanitarija. 2017; 96(11): 1115-8. (in Russian). https://doi.org/10.18821/0016-9900-2017-96-11-1115-8
  19. Gary A., Borkan Arthur H., Norris G. Assessment of biological age using a profile of physical parameters. J. Gerontol. 1980; 35: 177-84.
  20. Prohorov N.I., Dontsov V.I., Krut’ko V.N., Hodykina T.M. Biological age as a method of assessing the risks of health changes caused by natural, climatic and environmental factors. Analysis of the prognostic significance of the environmental rating of the Russian Federation regions. “Modern problems of assessment, forecasting and management of environmental risks to public health and the environment, ways of their rational solution”. Materials of the III international forum of the Scientific Council of the Russian Federation on human ecology and environmental hygiene 13-14 December 2018. [Materialy III Mezhdunarodnogo foruma Nauchnogo soveta Rossijskoj Federacii po jekologii cheloveka i gigiene okruzhajushhej sredy 13-14 dekabrja 2018]. Moscow; 2018: 294-7. (in Russian).
  21. Krut’ko V.N., Dontsov V.I., Zahar’jashheva O.V., Kuznecov I.A., Mamikonova O.A., Pyrvu V.V. et al. Biological age as an indicator of the level of health, aging, and environmental well-being of the person. Aviakosmicheskaja i jekologicheskaja medicina. 2014; 48(3): 2-19. (in Russian).
  22. Dontsov V.I., Krut`ko V.N. Aging: a systematic approach. Trudy ISA RAN. 2017; 67(1): 104-12. (in Russian).
  23. Karasik D., Demissie S., Cupples A., Kiel D. Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures. J. gerontol. A. Biol. Sci. Med. Sci. 2005; 60: 574-87.
  24. Dontsov V.I., Krut`ko V.N. Biological age : quantitative diagnosis of aging and risk of mortality. Certificate of state registration of computer programs № 2016663535 RF. 2016. (in Russian). https://doi.org/10.1093/geronb/gbr039
  25. Holin V.A., Bachinskaya N.Yu., Bezrukov V.V. Neurofunctional biological age in the elderly with the syndrome of moderate cognitive impairment. Ukrainian neurological journal. 2007; 4 (5): 024-8. (in Russian).
  26. MacDonald S.W, DeCarlo C.A., Dixon R.A. Linking biological and cognitive aging: toward improving characterizations of developmental time. J Gerontol B Psychol Sci Soc Sci. 2011; 66(Suppl 1): i59-70. https://doi.org/10.1093/geronb/gbr039
  27. Dontsov V.I., Krutko V.N. Biological age as a method for systematic assessment of ontogenetic changes in the state of an organism. Russian Journal of Developmental Biology. 2015; 46(5): 246-53. https://doi.org/10.1134/S1062360415050033
  28. Sprott R.L. Biomarkers of aging and disease: Introduction and definitions. Exp. Gerontol. 2010; 45: 2-4. https://doi.org/10.1016/j.exger.2009.07.008
  29. Plakueva A.N., Hromova A.V., Katysheva L.V., Popov D.S. . Biological age of young people living in conditions of European North. Jekologija cheloveka. 2006; 11: 17-20. (in Russian).
  30. Kusjakova R.F. . Physical activity and biological age. Mezhdunarodnyj nauchno-issledovatel’skij zhurnal. 2016; 8-5(50): 42-4. (in Russian). https://doi.org/10.18454/IRJ.2016.50.107
  31. Artem’eva N.K., Stepurenko V.V., Abakumova M.V. The relationship between the adequacy of nutrition and parameters of the biological age of athletes of high qualification. Resursy konkurentosposobnosti sportsmenov: teorija i praktika realizacii. 2015; 3: 7-9. (in Russian).
  32. Zelenin V.A., Pavlova G.V.Biological age of human, chronobiological indicator of tactics of prevention and treatment of diseases. Kurortnaja medicina. 2018; 3: 45-7. (in Russian).

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Copyright (c) 2019 Prokhorov N.I., Dontsov V.I., Krutko V.N., Khodykina T.M.


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