Estimation of the structure of the inhalation risk of immune disorders in the multi-route intake of pollutants

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Abstract

Introduction. People spend most of the time in rooms, where the air quality can differ in the atmospheric content of pollutants. 

The aim of the study is to evaluate the contribution of indoor air pollution to the formation of risks of immune disorders in adolescents in the case of multi-route administration of immunotropic compounds. 

Material and Methods. The study included 520 adolescents aged 12-17 years living in industrial centers with chemical and petrochemical industry enterprises and exposed to industrial emissions of the rural settlement. The content of chemical ingredients is studied in the atmospheric air, the air in residential and educational premises. Inhalation personalized hazard indices (PHIs) of immunity disorders for adolescents are calculated. 

Results. PHIs disorders of the immune system due to air pollution vary in the range from 0.87 to 3.91 with the multi-route intake of pollutants. PHIs immunity disorders due to air pollution are in the range of 0.7-1.1. PHIs, caused by exposure to indoor air pollutant, reached a value of 2.3 in a city with a central gas supply and a rural settlement with stove heating. Pollution of the air environment of classrooms has the least impact on the formation of risks of immunity disorders, due to them PHIs <0.22. 

Discussion. Since the intensity of the impact of chemical compounds on the body of adolescents is greatest under the influence of the indoor air, it is necessary to carry out activities aimed at improving its quality. 

Conclusion. Adolescents living in urbanized and rural areas are exposed to the increased danger of immune disorders due to the air pollution in out-door and in-door the premises.

About the authors

Liudmila B. Masnavieva

East-Siberian Institute of Medical and Ecological Research

Author for correspondence.
Email: Masnavieva_Luda@mail.ru
ORCID iD: 0000-0002-1400-6345

MD, Ph.D., senior researcher of the Laboratory of immunological, biochemical, molecular and genetic research in hygiene of the East-Siberian Institute of Medical and Ecological Research, 665827, Angarsk, Russian Federation. 

e-mail: Masnavieva_Luda@mail.ru

Russian Federation

N. V. Efimova

East-Siberian Institute of Medical and Ecological Research

Email: noemail@neicon.ru
ORCID iD: 0000-0001-7218-2147
Russian Federation

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