Search for New Potential T-Cell and B-Cell Epitopes in the Spike Protein of SARS-CoV-2

I. A. Kolesnikov; Колесников И. А.; V. I. Timofeev; Тимофеев В. И.; M. V. Nikolenko; Николенко М. В.; A. V. Ermakov; Ермаков А. В.; A. S. Ivanovsky; Ивановский А. С.; Yu. A. Dyakova; Дьякова Ю. А.; Yu. V. Pisarevsky; Писаревский Ю. В.; M. V. Kovalchuk; Ковальчук М. В.

doi:10.31857/S0023476123600106

Search for New Potential T-Cell and B-Cell Epitopes in the Spike Protein of SARS-CoV-2

Authors: Kolesnikov I.A.¹, Timofeev V.I.¹^,2, Nikolenko M.V.¹, Ermakov A.V.¹, Ivanovsky A.S.², Dyakova Y.A.¹, Pisarevsky Y.V.²^,1, Kovalchuk M.V.¹^,2
Affiliations:
1. National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia
2. Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia
Issue: Vol 68, No 6 (2023)
Pages: 959-970
Section: КРИСТАЛЛОГРАФИЯ В БИОЛОГИИ И МЕДИЦИНЕ
URL: https://rjmseer.com/0023-4761/article/view/673312
DOI: https://doi.org/10.31857/S0023476123600106
EDN: https://elibrary.ru/YEZWPQ
ID: 673312

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Abstract

The current epidemiological situation, including the existence of new SARS-CoV-2 virus with a high mutagenicity, requires fundamentally new deadlines for the development of vaccines, which may be achieved only applying modern computing technologies and simulation. Epitopes have been found in the spike protein of the SARS-CoV-2 virus using immunoinformatics methods, and their allergenicity and immunogenecity was predicted. It is shown that a vaccine against SARS-CoV-2 can be designed based on these epitopes.

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