Iron(III) Complexation with Barbituric and 2-Thiobarbituric Acids in Aqueous Solution

A. P. Lakeev; Лакеев А. П.; N. M. Korotchenko; Коротченко Н. М.; I. A. Kurzina; Курзина И. А.

doi:10.31857/S0044457X22601171

Iron(III) Complexation with Barbituric and 2-Thiobarbituric Acids in Aqueous Solution

Authors: Lakeev A.P.¹^,2, Korotchenko N.M.¹, Kurzina I.A.¹
Affiliations:
1. National Research Tomsk State University
2. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Issue: Vol 68, No 1 (2023)
Pages: 87-95
Section: ФИЗИКОХИМИЯ РАСТВОРОВ
URL: https://rjmseer.com/0044-457X/article/view/665331
DOI: https://doi.org/10.31857/S0044457X22601171
EDN: https://elibrary.ru/GVMHIC
ID: 665331

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Abstract

Complexation in systems containing iron(III) chloride and barbituric (H2BA) or 2-thiobarbituric (H2TBA) acid has been studied by spectrophotometry and pH-metry in the pH range of 1.3–3.3 (I = 0.1 (NaCl), t = 20°C). The presence of 1 : 1 complexes with mono- and deprotonated forms of the ligand has been established, and their stability constants (in log units) have been determined: 1[FeHBA]2+ (3.49 ± 0.15), [FeHTBA]2+ (2.69 ± 0.07), [FeBA]+ (12.22 ± 0.13), and [FeTBA]+ (11.05 ± 0.08). It has been shown that the higher thermodynamic stability of barbiturate complexes compared to 2-thiobarbiturate ones is due to the greater basicity of the barbiturate anion. Based on the stability constants obtained, it has been proposed to use orthophosphate, fluoride, and ethylenediaminetetraacetate ions to eliminate the interfering effect of iron(III) in the determination of malondialdehyde by the thiobarbiturate method. Orthophosphoric acid is the most convenient for practical applications, as it makes it possible to mask iron(III) and to create a strongly acidic medium necessary for the formation of a colored malondialdehyde–H2TBA adduct.

Keywords

barbituric acid, thiobarbituric acid, ferric ions, complex formation, stability constants

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