Synthesis and cytotoxic activity of novel chalcone analogues with pyridine-2,4(1H,3H)-dione fragment

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Abstract

New heterocyclic chalcone analogues with pyridine-2,4(1 Н ,3 Н )-dione fragment were synthesized by the condensation reaction of 3-acetylpyridine-2,4(1 H ,3 H )-diones with different aromatic aldehydes in pyridine in the presence of a catalytic amount of piperidine and acetic acid. Structures of the synthesized compounds were confirmed by of IR, 1H, 13C NMR spectroscopy methods and two-dimensional NMR spectroscopy methods and elemental analysis data. Cytotoxic activity of the series of obtained compounds was investigated in vitro against human cell lines of breast cancer (MCF-7) and liver cancer (Hep G2).

About the authors

T. S Khlebnicova

Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus

Email: khlebnicova@iboch.by

D. B Rubinov

Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus

A. V Baranovsky

Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus

F. A Lakhvich

Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus

F. S Pashkovsky

Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus

T. V Chukarina

Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus

S. E Ogurtsova

Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus

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