1,2,3-Triazole-Containing 1,5,6,7-Tetrahydro-4h-indazol-4-ones and 6,7-Dihydrobenzo[d]isoxazol-4(5h)-ones: Synthesis and Biological Activity

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Abstract

Triazole-containing 1,5,6,7-tetrahydro-4 H- indazol-4-ones and 6,7-dihydrobenzo[ d ]isoxazol-4(5 H )-ones were synthesized by cyclocondensation of 2-[(1 H -1,2,3-triazol-1-yl)acetyl]cyclohexane-1,3-diones with phenylhydrazine (4-fluorophenylhydrazine) or hydroxylamine, respectively. SStructure and composition of the obtained compounds were confirmed by 1H, 13C, 19F NMR spectroscopy methods and by data of elemental analysis. Cytotoxic and cytostatic activities of the series of obtained compounds were investigated in vitro against human hepatocellular carcinoma cells HepG2, mammary adenocarcinoma cells MCF-7 and laryngeal cancer cells Hep2.

About the authors

T. S Khlebnicova

Institute of Bioorganic chemistry, National Academy of Sciences of Belarus

Email: khlebnicova@iboch.by

V. G Zinovich

Institute of Bioorganic chemistry, National Academy of Sciences of Belarus

Yu. A. Piven

Institute of Bioorganic chemistry, National Academy of Sciences of Belarus

A. V Baranovsky

Institute of Bioorganic chemistry, National Academy of Sciences of Belarus

F. A Lakhvich

Institute of Bioorganic chemistry, National Academy of Sciences of Belarus

R. E Trifonov

St. Petersburg State Institute of Technology (Technical University)

Yu. A. Golubeva

A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences;Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine

L. S Klyushova

Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine

E. V Lider

A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences

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