Biginelli reaction in the synthesis of ethyl 4-(6-aryl-5-benzoyl-4-hydroxy-2-thioxohexahydropyrimidine-4-carboxamido)benzoates

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Abstract

Three-component Biginelli reaction of ethyl 4-(2,4-dioxo-4-phenylbutanamido)benzoate, aromatic aldehyde and thiourea in acetic acid in the presence of sodium acetate led to the formation of ethyl 4-(6-aryl-5-benzoyl4-hydroxy-2-thioxohexahydropyrimidine-4-carboxamido)benzoates. Structure of the obtained compounds was established by IR, 1H NMR, 13C spectroscopy methods.

About the authors

V. L Gein

Perm State Pharmaceutical Academy

Email: geinvl48@mail.ru

T. M Zamaraeva

Perm State Pharmaceutical Academy

E. V Gorgopina

Perm State Pharmaceutical Academy

M. V Dmitriev

Perm State National Research University

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