Synthesis of 3,5-dichlorosalicylic acid anilides bearing a carboxymethoxyl group in aniline fragment

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Abstract

Reaction of (aminodichlorophenoxy)acetic acids with 3,5-dichlorosalicylic acid chloride in acetonitrile produced salicylanilides containing carboxymethoxyl group in aniline fragment. The yield of the target compounds depends on the structure of the acylated amine and the order of addition of amine, acid chloride and proton acceptor. Also, the synthesis procedure of some intermediates necessary for the synthesis, in particular 2,6-dichloro-4-nitrophenoxyacetic acid methyl ester, was improved.

About the authors

V. G. Dudarev

St. Petersburg State Chemical and Pharmaceutical University

Email: vladimir.dudarev@pharminnotech.com

M. I. Vasendin

St. Petersburg State Chemical and Pharmaceutical University

A. V. Moskvin

St. Petersburg State Chemical and Pharmaceutical University

D. S. Lisovsky

St. Petersburg State Chemical and Pharmaceutical University

N. V. Kolotilova

St. Petersburg State Chemical and Pharmaceutical University

B. Y. Lalaev

St. Petersburg State Chemical and Pharmaceutical University

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