Synthesis and Structure of Ethyl 4-Aryl-2-oxo-2,3,4,10-tetrahydrobenzo[4,5]imidazo[1,2- a ]pyrimidine-3-carboxylates

K. V. Podchezertseva; Подчезерцева К. В.; T. M. Zamaraeva; Замараева Т. М.; N. V. Slepova; Слепова Н. В.; M. V. Dmitriev; Дмитриев М. В.

doi:10.31857/S0044460X24060034

Synthesis and Structure of Ethyl 4-Aryl-2-oxo-2,3,4,10-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylates

Authors: Podchezertseva K.V.¹, Zamaraeva T.M.¹, Slepova N.V.¹, Dmitriev M.V.²
Affiliations:
1. Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
2. Perm State National Research University
Issue: Vol 94, No 6 (2024)
Pages: 699-704
Section: Articles
URL: https://rjmseer.com/0044-460X/article/view/667383
DOI: https://doi.org/10.31857/S0044460X24060034
EDN: https://elibrary.ru/EZRMQF
ID: 667383

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Abstract

Ethyl 4-aryl-2-oxo-2,3,4,10-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylates were prepared by three-component one-pot condensation of diethylmalonate, aromatic aldehyde, 2-aminobenzimidazole in ethanol in the presence of piperidine. The structure of the obtained compounds was determined by ¹H, ¹³С NMR spectroscopy and single crystal X-ray diffraction analysis.

Keywords

malonic acid diethyl ether, arylaldehydes, 2-aminobenzimidazole, piperidine, three-component reaction

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About the authors

K. V. Podchezertseva

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: tanyapgfa@yandex.ru
ORCID iD: 0009-0009-7473-5505
Russian Federation, Perm

T. M. Zamaraeva

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: tanyapgfa@yandex.ru
ORCID iD: 0000-0002-9932-9628
Russian Federation, Perm

N. V. Slepova

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: tanyapgfa@yandex.ru
ORCID iD: 0000-0003-3924-3715
Russian Federation, Perm

M. V. Dmitriev

Perm State National Research University

Email: tanyapgfa@yandex.ru
ORCID iD: 0000-0002-8817-0543
Russian Federation, Perm

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