Photonics of bilirubin – biologically important molecule (Review)

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Resumo

Bilirubin, a bile pigment having photochemical activity, plays an important role in the body. Photonics (photophysics and photochemistry) of bilirubin has attracted scientific and practical interest of researchers up to the present day. This is because its molecule is capable of ultrafast photoisomerization processes, and also contains two interacting dipyrromethenone chromophores. Furthermore, the photochemical reactions of bilirubin are used in the widespread phototherapy of neonatal jaundice (neonatal hyperbilirubinemia), carried out to reduce the level of bilirubin in the body. This review briefly considers photonics of bilirubin, as well as its main photochemical reactions in phototherapy of neonatal hyperbilirubinemia.

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Sobre autores

A. Tatikolov

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

Autor responsável pela correspondência
Email: tatikolov@mail.ru
Rússia, Moscow

I. Panova

International Scientific and Practical Center of Tissue Proliferation

Email: tatikolov@mail.ru
Rússia, Moscow

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2. Fig. 1. Structure of the BR molecule.

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3. Fig. 2. Structure of the Z,Z-conformation of BR – 4Z,15Z-bilirubin-IXα. Dashed lines show intramolecular hydrogen bonds stabilizing the Z,Z-conformation. Arrows point to double bonds 4–5 and 15–16, relative to which BR photoisomerization occurs.

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4. Fig. 3. Structure of lumirubin (cyclobilirubin).

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