Nanosized platform based on magnetic nanoparticles for photodynamic therapy in oncology

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Hybrid nanosystems based on iron oxide nanoparticles (IONPs) and human serum albumin (HSA) have been synthesized. Size and composition of HSA@IONPs nanosystems were characterized using UV/visible spectrophotometry (particularly, using the Bradford protein assay), dynamic light scattering and electron magnetic resonance. Methylene blue, as a model photosensitizer, was non-covalently bound to the nanosystems (5.8 μg per 1 mg of IONPs). The nanosystems were subjected to phototoxicity studies to confirm their suitability for photodynamic therapy, and the survival of cultured human breast adenocarcinoma MCF-7 tumor cells was analyzed. An increase in photoinduced cytotoxicity was observed when the photosensitizer was accumulated by cells upon delivery by the nanosystems, compared with a free photosensitizer at equivalent concentrations. HSA@IONPs are discussed as a promising platform for targeted delivery of a photosensitizer to tumor cells.

Толық мәтін

Рұқсат жабық

Авторлар туралы

A. Bychkova

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: anna.v.bychkova@gmail.com
Ресей, Moscow

A. Markova

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Ресей, Moscow

M. Nguyen

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Ресей, Moscow

M. Gradova

Semenov Federal Research Center for Chemical Physics of the Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Ресей, Moscow

M. Gorobets

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Ресей, Moscow

M. Motyakin

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Ресей, Moscow

M. Abdullina

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Ресей, Moscow

A. Toroptseva

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Ресей, Moscow

V. Kuzmin

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Ресей, Moscow

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1. JATS XML
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2. Fig. 1. Number of publications in the PubMed database by year, by the keyword “nanoparticles” and additional keywords indicated in the figure: “serum albumin”, “iron oxide”, “iron oxides”, “magnetite”.

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3. Fig. 2. Schematic representation of the stages of preparation of samples of hybrid nanosystems MS–(HSA@NCHO): obtaining nanoparticles in an albumin coating and non-covalent binding of nanoparticles to methylene blue.

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4. Fig. 3. Absorption spectra of methylene blue in water (1) and in the supernatant solution after magnetic separation of MS–(HSA@NCHO) (2).

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5. Fig. 4. Volume distributions of particle sizes obtained by dynamic light scattering in the control sample of NChOZh (left) and the experimental sample of ChSA@NChOZh (right).

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6. Fig. 5. Dark (1) and photoinduced cytotoxicity (2) of HSA@NCHO, MS–(HSA@NCHO) and MS on MCF-7 cells.

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