Action of Serotonin Precursor Synthesis 5-Oxytryptophan on EPSP Recorded in Premotor Interneurons of Snail after Formation of Conditioned Defensive Reflex

A. I. Arslanov; Арсланов А. И.; D. I. Silantyeva; Силантьева Д. И.; V. V. Andrianov; Андрианов В. В.; I. B. Deryabina; Дерябина И. Б.; Kh. L. Gainutdinov; Гайнутдинов Х. Л.

doi:10.31857/S0233475523050031

Action of Serotonin Precursor Synthesis 5-Oxytryptophan on EPSP Recorded in Premotor Interneurons of Snail after Formation of Conditioned Defensive Reflex

Authors: Arslanov A.I.¹, Silantyeva D.I.¹, Andrianov V.V.¹^,2, Deryabina I.B.¹, Gainutdinov K.L.¹^,2
Affiliations:
1. Kazan Federal University
2. Zavoisky Physical-Technical Institute of the Federal Scientific Center of Russian Academy of Sciences
Issue: Vol 40, No 5 (2023)
Pages: 336-341
Section: Articles
URL: https://rjmseer.com/0233-4755/article/view/667331
DOI: https://doi.org/10.31857/S0233475523050031
EDN: https://elibrary.ru/OJJWQQ
ID: 667331

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Abstract

A quantitative study of subthreshold excitatory postsynaptic potentials (EPSP) recorded intracellularly in giant premotor interneurons of the terrestrial snail was carried out after the formation of a conditioned defensive reflex of food aversion in snails with increased level of serotonin. The results showed a significant increase in the number of low-amplitude EPSP with an amplitude from 0.3 to 0.5 mV in the giant premotor interneurons of defensive behavior after learning and increasing the level of serotonin. The observed increase in the number of EPSP may indicate either an increase in the number of action potentials in the corresponding presynaptic neurons or an increase in the amplitudes of the EPSP that were previously undetectable.

Keywords

neuron, training, EPSP, synaptic plasticity, membrane potential, serotonin

References

Losonczy A., Makara J.K., Magee J.C. 2008. Compartmentalized dendritic plasticity and input feature storage in neurons. J. Nature. 27 (452), 436–441.
Lisman J., Cooper K., Sehgal M., Silva A.J. 2018. Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability. Nat. Neurosci. 21 (3), 309–314.
Bliss T.V., Lomo T. 1973. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J. Physiol. 2 (232), 331–356.
Балабан П.М., Коршунова Т.А. 2011. Сетевые, клеточные и молекулярные механизмы пластичности в простых нервных системах. Успехи физиол. наук. 42 (4), 3–19.
Гайнутдинов Х.Л., Андрианов В.В., Гайнутдинова Т.Х. 2011. Изменение возбудимости нейрональной мембраны как клеточный механизм обучения и памяти. Успехи физиол. наук. 42 (1), 33–50.
Andrianov V.V. Bogodvid T.K., Deryabina I.B. 2015. Modulation of defensive reflex conditioning in snails by serotonin. Front. Behav. Neurosci. 9, 279.
Науменко Е.В., Попова Е.К. 1975. Серотонин и мелатонин в регуляции эндокринной системы. Новосибирск: Наука. 220 с.
Гайнутдинов Х.Л., Андрианов В.В., Гайнутдинова Т.Х., Тарасова Е.А. 1998. Электрические характеристики командных и моторных нейронов при выработке условного оборонительного рефлекса и формирования долговременной сенситизации у улиток. Журн. высш. нервн. деят. 48 (6), 1004–1013.
Deryabina I.B., Muranova L.N., Andrianov V.V., Gainutdinov K.L. 2018. Impairing of serotonin synthesis by p-chlorphenylanine prevents the forgetting of contextual memory after reminder and the protein synthesis inhibition. Front. Pharmacol. 9, 607.
Палихова Т.А., Маракуева И.В., Аракелов Г.Г. 1992. Моно- и полисинаптические связи между идентифицированными нейронами в системе пассивно-оборонительного рефлекса виноградной улитки. Журн. высш. нервн. деят. 42 (6), 1170–1179.
Балабан П.М., Захаров И.С. 1992. Обучение и развитие. Общая основа двух явлений. М.: Наука. 150 с.