Targeting Liposomes Loaded with DNA Mimetics for the Directional Elimination of Tumor Cells

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Abstract

The article presents an innovative method for the targeted elimination of tumor cells of a certain molecular profile by inactivating the transcription of genes of common subunits of human RNA polymerases using complementary DNA mimetics delivered into cells inside liposomes modified on the outer surface with targeting molecules. It was shown that inactivation of genes of RNA polymerase common subunits Rpb5, Rpb6, or Rpb8 by the proposed method, depending on the chosen target, causes death of up to 50% of HER2-positive human breast cancer cells in culture.

About the authors

E. I. Shramova

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Author for correspondence.
Email: shramova.e.i@gmail.com
Russia, 117997, Moscow

G. M. Proshkina

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: shramova.e.i@gmail.com
Russia, 117997, Moscow

S. M. Deyev

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Email: shramova.e.i@gmail.com
Russia, 117997, Moscow; Russia, 119991, Moscow

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