Heterocycles on the base of bis(trifluoromethyl)imidazolidin-2-ones, 2-aminoethanol and 2-aminophenol

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Resumo

Novel trifluoromethyl-containing imidazo-1,4-oxazines have been synthesized through the condensation reaction of 4,5-dihydroxy-4,5-bis(trifluoromethyl)imidazolidin-2-one with 2-aminoethanol (2-AE) and 2-aminophenol (2-APh). Unusual route of the reaction of 1-methyl(phenyl)- 4,5-dihydroxy-4,5-bis(trifluoromethyl)imidazolidin-2-ones with 2-AE has been found, leading to hydroxyethylamino-substituted hydantoins. The interaction of the N-substituted imidazolidines with 2-APh under similar conditions led to formation of rearrangement products, 5,5-bis(trifluoromethyl)hydantoins. The molecular structure of 5-[(2-hydroxyethyl)amino]-3-methyl-5-(trifluoromethyl)imidazolidin-2,4-dione has been studied by X-ray diffraction experiment.

Sobre autores

L. Saloutina

Postovsky Institute of Organic Synthesis of Ural Branch of Russian Academy of Sciences

Email: saloutinalv@yandex.ru

M. Kodess

Postovsky Institute of Organic Synthesis of Ural Branch of Russian Academy of Sciences;Ural Federal University named after the first President of Russia B.N. Yeltsin

Email: saloutinalv@yandex.ru

I. Ganebnykh

Postovsky Institute of Organic Synthesis of Ural Branch of Russian Academy of Sciences

Email: saloutinalv@yandex.ru

P. Slepukhin

Postovsky Institute of Organic Synthesis of Ural Branch of Russian Academy of Sciences;Ural Federal University named after the first President of Russia B.N. Yeltsin

Email: saloutinalv@yandex.ru

V. Saloutin

Postovsky Institute of Organic Synthesis of Ural Branch of Russian Academy of Sciences;Ural Federal University named after the first President of Russia B.N. Yeltsin

Email: saloutinalv@yandex.ru

O. Chupakhin

Postovsky Institute of Organic Synthesis of Ural Branch of Russian Academy of Sciences;Ural Federal University named after the first President of Russia B.N. Yeltsin

Email: saloutinalv@yandex.ru

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