Catalytic cross-cyclomagnesiation reaction in the synthesis of 4Z-unsaturated iodo-δ-lactones

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Abstract

A three-stage synthesis of 4 Z -unsaturated iodo-δ-lactones based on 5 Z ,9 Z -dienic acids was carried out using the intermolecular cross-cyclomagnesiation reaction of aliphatic and O-containing 1,2-dienes catalyzed by Cp2TiCl2 at the key stage with yields of 92-96% and selectivity 98-99%.

About the authors

A. A Makarov

Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences

Email: makarovalexink@gmail.com

I. V Ishbulatov

Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences

Email: makarovalexink@gmail.com

E. Kh. Makarova

Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences

Email: makarovalexink@gmail.com

V. A D'yakonov

N.D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences

Email: makarovalexink@gmail.com

U. M Dzhemilev

N.D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences

Email: makarovalexink@gmail.com

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