Synthesis of spiro[pyrrole-2,5′-pyrrolo[2,3-d]pyrimidines] by reaction of pyrrolobenzoxazinetriones with 6-aminouracil

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Abstract

3-Aroylpyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones react with 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione with formation of 3-aroyl-4-hydroxy-1-(2-hydroxyaryl)-1′,3′-dimethylspiro[pyrrole-2,5′-pyrrolo[2,3-d]-pyrimidine]-2′,4′,5,6′ (1H,1′H,3′H,7′H)-tetraons, the structure of which was confirmed by X-ray diffraction analysis. A simple method for constructing a hard-to-reach heterocyclic system of spiro[pyrrole-2,5′-pyrrolo[2,3-d]-pyrimidine] is described.

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About the authors

A. I. Kobelev

Perm State University

Email: koh2@psu.ru
ORCID iD: 0000-0001-8606-7908
Russian Federation, ul. Bukireva, 15, Perm, 614990

M. V. Dmitriev

Perm State University

Email: koh2@psu.ru
ORCID iD: 0000-0002-8817-0543
Russian Federation, ul. Bukireva, 15, Perm, 614990

A. N. Maslivets

Perm State University

Author for correspondence.
Email: koh2@psu.ru
ORCID iD: 0000-0001-7148-4450
Russian Federation, ul. Bukireva, 15, Perm, 614990

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3. Fig. General view of the molecule of 3-benzoyl-4-hydroxy-1-(2-hydroxyphenyl)-1′,3′-dimethylspiro[pyrrole-2,5′-pyrrolo[2,3-d]pyrimidine]-2′,4′,5,6′ (1H,1′H,3′H,7′H)-tetraone (2a) according to X-ray diffraction data in thermal ellipsoids of 30% probability

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