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Substituted ureas and their analogues containing framework fragments. I. 1-(4-hydroxyadamanthane-1-yl)-3-(fluo, chlorophenyl)ureas
- Authors: Danilov D.V.1, D’yachenko V.S.1, Zapravdina D.M.1, Ilyina E.S.1, Degtyarenko E.K.1, Burmistrov V.V.1
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Affiliations:
- Volgograd state technical university
- Issue: Vol 60, No 12 (2024)
- Pages: 1195-1203
- Section: Articles
- URL: https://rjmseer.com/0514-7492/article/view/681811
- DOI: https://doi.org/10.31857/S0514749224120029
- EDN: https://elibrary.ru/QEWUPY
- ID: 681811
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Abstract
This work begins a new series of articles devoted to di-, tri- and tetra-substituted urea derivatives and is a continuation of research [1] on modification of the framework fragment in molecules of adamantyl-containing ureas. By the reaction of 1-(4-oxoadamant-1-yl)-3-(halophenyl)ureas with sodium borohydride, a series of 1,3-disubstituted ureas containing a 4-hydroxyadamantan-1-yl radical in their structure was synthesized, with a yield of target products of 55–87%. The synthesized ureas are potential metabolites and promising inhibitors of soluble human epoxide hydrolase (sEH).
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About the authors
D. V. Danilov
Volgograd state technical university
Email: vburmistrov@vstu.ru
ORCID iD: 0000-0001-8734-2617
Russian Federation, prosp. Lenina, 28, Volgograd, 400005
V. S. D’yachenko
Volgograd state technical university
Email: vburmistrov@vstu.ru
ORCID iD: 0000-0002-6209-7106
Russian Federation, prosp. Lenina, 28, Volgograd, 400005
D. M. Zapravdina
Volgograd state technical university
Email: vburmistrov@vstu.ru
ORCID iD: 0000-0002-8654-2382
Russian Federation, prosp. Lenina, 28, Volgograd, 400005
E. S. Ilyina
Volgograd state technical university
Email: vburmistrov@vstu.ru
ORCID iD: 0009-0005-0475-1113
Russian Federation, prosp. Lenina, 28, Volgograd, 400005
E. K. Degtyarenko
Volgograd state technical university
Email: vburmistrov@vstu.ru
ORCID iD: 0000-0002-7337-4885
Russian Federation, prosp. Lenina, 28, Volgograd, 400005
V. V. Burmistrov
Volgograd state technical university
Author for correspondence.
Email: vburmistrov@vstu.ru
ORCID iD: 0000-0002-8547-9166
Russian Federation, prosp. Lenina, 28, Volgograd, 400005
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