Effect of Peroxynitrite and tert-Butyl Hydroperoxide on Thiol Ligands of Dinitrosyl Iron Complexes

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Low molecular weight dinitrosyl iron complexes (DNICs) with thiol-containing ligands are a physiological form for deposit and transport of nitric oxide (NO) in the organism, herewith DNICs can exhibit antioxidant and antiradical properties. It was that DNICs containing cysteine, glutathione and lipoic acid as ligands, decreased the rate of dihydrodamine oxidation by peroxynitrite formed during 3-morpholinononymine decomposition. Thiol (sulfhydryl) ligands are present in DNICs in the form of thiolate anions (R-S−), which protects these groups from oxidation by peroxynitrite. When tert-butyl peroxide was used as an oxidizer at low concentration, the protective effect of DNICs on their SH-groups was observed for complexes with lipoic acid (LA-DNIC) and with glutathione (GS-DNIC). LA-DNIC was more resistant to oxidizing agents and more effective peroxynitrite trap than other DNICs. DNICs associated with bovine serum albumin had a negligible protective effect on cysteine residue during oxidation by peroxynitrite and tert-butyl hydroperoxide. The obtained results allow us to consider low molecular weight DNICs with thiol ligands as peroxynitrite traps and thiol residues protectors in proteins.

作者简介

I. Pugachenko

Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences

Email: aftopunov@yandex.ru
Russia, 119071, Moscow

E. Nasybullina

Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences

Email: aftopunov@yandex.ru
Russia, 119071, Moscow

O. Kosmachevskaya

Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences

Email: aftopunov@yandex.ru
Russia, 119071, Moscow

K. Shumaev

Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences

Email: aftopunov@yandex.ru
Russia, 119071, Moscow

A. Topunov

Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences

编辑信件的主要联系方式.
Email: aftopunov@yandex.ru
Russia, 119071, Moscow

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版权所有 © И.С. Пугаченко, Э.И. Насыбуллина, О.В. Космачевская, К.Б. Шумаев, А.Ф. Топунов, 2023