The effect of dalargin on the level of corticosterone in rats with different individual typological features of behavior in the PTSD model

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Abstract

The effect of the synthetic analogue of leu-enkephalin (dalargin) on the level of corticosterone in the blood and the mass of the adrenal glands in rats with various typological features of behavior in the model of post-traumatic stress disorder (PTSD) was studied. Groups were formed: active low-anxiety (ALA) and high-anxiety (AHA), as well as passive low-anxiety (PLA) and high-anxiety (PHA) rats. Each of the 4 groups of rats was divided into 3 subgroups, where subgroup 1 is an intact control. 20 days after the first stressful exposure, rats from subgroup 3 were injected intramuscularly with the dalargin for 7 days, and rats from subgroup 2 were injected with the saline solution. It was found that the course of injections of dalargin into rats in the PTSD model had a positive effect on the studied indicators only in the group of active highly-anxiety animals.

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O. G. Semenova

I. P. Pavlov Institute of Physiology, Russian Academy of Sciences

Author for correspondence.
Email: Pritvorovaav@infran.ru
Russian Federation, 199034, St. Petersburg, Makarova emb., 6

A. V. Vyushina

I. P. Pavlov Institute of Physiology, Russian Academy of Sciences

Email: Pritvorovaav@infran.ru
Russian Federation, 199034, St. Petersburg, Makarova emb., 6

A. V. Pritvorova

I. P. Pavlov Institute of Physiology, Russian Academy of Sciences

Email: Pritvorovaav@infran.ru
Russian Federation, 199034, St. Petersburg, Makarova emb., 6

S. G. Pivina

I. P. Pavlov Institute of Physiology, Russian Academy of Sciences

Email: Pritvorovaav@infran.ru
Russian Federation, 199034, St. Petersburg, Makarova emb., 6

N. E. Ordyan

I. P. Pavlov Institute of Physiology, Russian Academy of Sciences

Email: Pritvorovaav@infran.ru
Russian Federation, 199034, St. Petersburg, Makarova emb., 6

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