Аnticoagulation Effects of Leucine-Containing Glyprolines in Hypercoagulation

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The effects of two leucine-containing glyproline peptides Leu-Pro-Gly-Pro and Pro-Gly-Pro-Leu, including leucine from the N- and C-ends of the molecules, on the parameters of platelet (primary) and plasma hemostasis were studied. Peptides were administered intranasally for 5 days at a daily dose of 500 mcg/kg of body weight under conditions of hypercoagulation caused by intravenous administration of tissue thromboplastin to metabolic syndrome rats on high-calorie diet. Both peptides contributed to an increase in all types of fibrinolysis (total, enzymatic and non-enzymatic), anticoagulant activity and a decrease in platelet aggregation in rat blood plasma compared with the control. The maximum anticoagulant effect was established in a peptide containing leucine from the C-terminus.

Sobre autores

M. Grigorieva

Lomonosov Moscow State University, Biology Faculty, Department of Human and Animal Physiology, Laboratory of Protective Blood Systems named after prof. B.A. Kudryashov

Autor responsável pela correspondência
Email: mgrigorjeva@mail.ru
Russia, 119234, Moscow, Leninsky Gory, 1/12

T. Obergan

Lomonosov Moscow State University, Biology Faculty, Department of Human and Animal Physiology, Laboratory of Protective Blood Systems named after prof. B.A. Kudryashov

Email: mgrigorjeva@mail.ru
Russia, 119234, Moscow, Leninsky Gory, 1/12

L. Lyapina

Lomonosov Moscow State University, Biology Faculty, Department of Human and Animal Physiology, Laboratory of Protective Blood Systems named after prof. B.A. Kudryashov

Email: mgrigorjeva@mail.ru
Russia, 119234, Moscow, Leninsky Gory, 1/12

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Declaração de direitos autorais © М.Е. Григорьева, Т.Ю. Оберган, Л.А. Ляпина, 2023