Study of Surface Morphology of Microfluidic Chip Channels via X-Ray Tomography and Scanning Electron Microscopy

S. V. Chapek; Чапек С. В.; I. A. Pankin; Панкин И. А.; D. V. Khodakova; Ходакова Д. В.; A. A. Guda; Гуда А. А.; A. S. Goncharova; Гончарова А. С.; A. V. Soldatov; Солдатов А. В.

doi:10.31857/S1028096023030032

Study of Surface Morphology of Microfluidic Chip Channels via X-Ray Tomography and Scanning Electron Microscopy

Authors: Chapek S.V.¹, Pankin I.A.¹, Khodakova D.V.², Guda A.A.¹, Goncharova A.S.², Soldatov A.V.¹
Affiliations:
1. Smart Materials International Research Institute, Southern Federal University
2. National Medical Research Centre for Oncology
Issue: No 3 (2023)
Pages: 92-97
Section: Articles
URL: https://rjmseer.com/1028-0960/article/view/664601
DOI: https://doi.org/10.31857/S1028096023030032
EDN: https://elibrary.ru/LGOIBS
ID: 664601

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription Access

Abstract

The visualization of microfluidic chips was considered to study morphology of microfluidic channel surface and estimate the quality of 3D printing technology based on digital light processing. The visualization was performed by X-ray microtomography using different iodine-based contrast agents and by scanning electron microscopy. It was shown that X-ray microtomography visualization made it possible to control the quality of device printing relative to geometrical parameters of the models specified at the prototyping stage, as well as to visualize a 3D model of microfluidic channels and surface morphology. The spatial resolution of scanning electron microscopy exceeds the print pixel size and makes it possible to clarify the presence of local defects caused by uneven solidification of the resin during sample washing.

Keywords

microfluidic systems, 3D printing, X-ray tomography, microtomography, scanning electron microscopy.

References

Song Y., Kumar H.J., Kumar C.S.S.R. // Small. 2008. V. 4. № 6. P. 698.https://doi.org/10.1002/smll.200701029
Lai X., Lu B., Zhang P., Zhang X., Pu Z., Yu H., Li D. // ACS Biomater. Sci. Eng. 2019. V. 5. № 12. P. 6801.https://doi.org/10.1021/acsbiomaterials.9b00953
Ma J., Lee S, Yi M.Y., Li. C. // Lab Chip. 2017. V. 17. № 2. P. 209.https://doi.org/10.1039/C6LC01049K
Noviana E., Ozer T., Carrell C.S., Link J.S., McMahon C., Jang I., Henry C.S. // Chem. Rev. 2021. V. 121. № 19. P. 11835.https://doi.org/10.1021/acs.chemrev.0c01335
Niculescu A.-G., Chircov C., Bîrcă A.C., Grumezescu A.M. // Int. J. Mol. Sci. 2021. V. 22. № 4. P. 2011.https://doi.org/10.3390/ijms22042011
Hwang J., Cho Y.H., Park M.S., Kim B.H. // Int. J. Precis. Eng. Manuf. 2019. V. 20. № 3. P. 479.https://doi.org/10.1007/s12541-019-00103-2
Hamdallah S.I, Zoqlam R., Erfle P., Blyth M., Alkilany A.M., Dietzel A., Qi S. // Int. J. Pharm. 2020. № 584. P. 119408.https://doi.org/10.1016/j.ijpharm.2020.119408
Wang Y., Seidel M. // Sensors. 2021. V. 21. № 7. P. 2290. https://doi.org/10.3390/s21072290
Hakke V., Sonawane S., Anandan S., Sonawane, Ashokkumar S. // Nanomaterials. 2021. V. 11. № 1. P. 98.https://doi.org/10.3390/nano11010098
Shrimal P., Jadeja G., Patel S. // Chem. Eng. Res. Des. 2020. V. 153. P. 728. https://doi.org/10.1016/j.cherd.2019.11.031
Srikanth S., Dudala S., Jayapiriya U.S., Mohan J.M., Raut S., Dubey S.K., Ishii I., Goel J.A. // Sci. Rep. 2021. V. 11. № 1. P. 9750. https://doi.org/10.1038/s41598-021-88068-z
Schaap A., Koopmans D., Holtappels M., Dewar M., Arundell M., Papadimitriou S., Hanz R.,Monk S., Mowlem M., Loucaides S. // Int. J. Greenh. Gas Control. 2021. V. 110. P. 103427. https://doi.org/10.1016/j.ijggc.2021.103427
Narayanamurthy V., Jeroish Z.E., Bhuvaneshwari K.S., Bayat P., Premkumar R., Samsuri F., Yusoff M.M. // RSC Adv. 2020. V. 10. № 20. P. 11652. https://doi.org/10.1039/D0RA00263A
Tymm C., Zhou J., Tadimety A., Burklund A., Zhang J.X.J. // Cell. Mol. Bioeng. 2020. V. 13. № 4. P. 313. https://doi.org/10.1007/s12195-020-00642-z
Bressan L.P., Lima T.M., da Silveira G.D., da Silva J.A.F. // Appl. Sci. V. 2. № 5. P. 984. https://doi.org/10.1007/s42452-020-2768-2
Gonzalez G,. Roppolo I., Pirri C.F., Chiappone A. // Additive Manufacturing. V. 55. P. 102867. https://doi.org/10.1016/j.addma.2022.102867
De Costa B.M., Griveau S, Bedioui F., Orlye F., da Silva J.A.F., Varenne A. // Electrochim. Acta. 2022. № 407. P. 139888. https://doi.org/10.1016/j.electacta.2022.139888
Nguyen H.Q., Seo T.S. // Anal. Chim. Acta. 2022. № 1192. P. 339344. https://doi.org/10.1016/j.aca.2021.339344
Fritschen A., Bell A.K., Königstein I., Stühn L., Stark, Blaeser R.W. // Biomater. Sci. 2022. V. 10. № 8. P. 1981. https://doi.org/10.1039/D1BM01794B
Van der Linden P.J.E.M., Popov A.M., Pontoni // Lab. Chip. 2020. V. 20. № 22. P. 4128. https://doi.org/10.1039/D0LC00767F
Jahanbakhsh A., Wlodarczyk K.L., Hand D.P., Maier R.R.J., Maroto-Valer M.M. // Sensors. 2020. V. 20. № 14. P. 4030. https://doi.org/10.3390/s20144030
Kumar M., Knackstedt M.A., Senden T.J., Sheppard A.P., Middleton J.P. // Petrophys. 2010. V. 51. № 05. P. SPWLA-2010-v51n5a4. https://onepetro.org/petrophysics/article-abstract/171223/Visualizing-And-Quantifying-the-Residual-Phase?redirectedFrom=fulltext,
Schuler J., Kockmann N. // AIChE J. 2020. V. 66. № 4. P. 16890.https://doi.org/10.1002/aic.16890
Costa P.F., Albers H.J., Linssen J.E.A., Middelkamp H.H.T., van der Hout L., Passier R., van den Berg A., Malda J., Van der Meer A. // Lab. Chip. 2017. V. 17. № 16. P. 2785. https://doi.org/10.1039/C7LC00202E
Everhart T.E., Thornley R.F. // J. Sci. Instrum. 1960. V. 37. № 7. P. 246. https://doi.org/10.1088/0950-7671/37/7/307