Assessment of the incidence of uterine cancer in the Chechen Republic
- Authors: Idrisova L.S.1
-
Affiliations:
- Republican Clinical Center for Maternal and Child Health named after Aimani Kadyrova
- Issue: Vol 25, No 3 (2022)
- Pages: 163-170
- Section: Original study articles
- URL: https://rjmseer.com/1560-9537/article/view/112153
- DOI: https://doi.org/10.17816/MSER112153
- ID: 112153
Cite item
Abstract
BACKGROUND: Malignant reproductive system neoplasms are an important medical and socio-economic problem. Therefore, it is important to study the natural history of gynecological oncopathology.
AIM: to assess the incidence of uterine cancer (UC) in the Chechen Republic (CR) and perform a comparative analysis of oncological care in the North Caucasian Federal District (NCFD) and Russia as a whole.
MATERIALS AND METHODS: We studied patients with UC from 2014 to 2020. The morbidity rates, patients under medical observation, pathological confirmation of the diagnosis, disease stages, mortality, and treatment were assessed. The research methods included examination of documents, data copying, statistical analysis and graphic representations.
RESULTS: The incidence of UC in Russia is growing, currently the crude rate of 28.79%, and standardized rate of 15.13% with an average annual growth rate of 2.49 and 1.40%, respectively (the difference is statistically significant). In the CR, the proportion of patients in whom UC was detected at stage I was less, and at the second stage, the detection rate was higher than the rates in the NCFD and in Russia. However, in the CR, the proportion of patients with UC diagnosed at stage III is 2.3 times higher than in the district and in Russia. Mortality in the first year after diagnosis in the CR was 6.5% (in Russia it was 7.6%, in the NCFD 6.8%). In the CR, compared to NCFD and Russia, there were lower rates of actively detected patients with UC, of patients who registered with dispensaries for 5 years or more, and of patients who completed treatment in the year the disease was detected.
CONCLUSION: The results of comparative assessment of the incidence of UC in the CR region, the NCFD, and Russia should be used to determine priority areas for diagnosis, treatment, and rehabilitation measures, taking into account regional characteristics. It is extremely important to monitor risk factors and implement preventive programs in this priority area of public health.
Keywords
Full Text
About the authors
Lilya S. Idrisova
Republican Clinical Center for Maternal and Child Health named after Aimani Kadyrova
Author for correspondence.
Email: rkcozmir_ak@mail.ru
ORCID iD: 0000-0001-5931-0175
SPIN-code: 9996-4623
MD, Cand. Sci. (Med.)
Russian Federation, GroznyReferences
- Kaprin AD, Ashrafyan LA, Stilidi IS, editors. Gynecologic Oncology. National Guide. Moscow: GEOTAR-Media; 2019. 384 p. (In Russ). doi: 10.33029/9704-5329-2-ONR-2019-1-384
- Gordienko VP, Leont’eva SN, Korobkova TN. Cancer of the reproductive organs in women of the Far Eastern Federal District. Siberian journal of oncology. 2020;19(3):23–37. (In Russ). doi: 10.21294/1814-4861-2020-19-2-23-37
- Odintsova IN, Pisareva LF, Pikalova LV, Kudyakov LA. Epidemiological aspects of the main localizations of gynecological cancer in the Tomsk region. Siberian journal of oncology. 2017;16(5):48–54. (In Russ). doi: 10.21294/1814-4861-2017-16-5-48-54
- Kalampokas E, Giannis G, Kalampokas T, et al. Current approaches to the management of patients with endometrial cancer. Cancers (Basel). 2022;14(18):4500. doi: 10.3390/cancers14184500
- Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J. Clin. 2019;69(1):7–34. doi: 10.3322/caac.21551
- Kandoth C, Schultz N, Cherniack AD, et al. Integrated genetic characterization of endometrial carcinoma. Project: Cancer Genome Atlas Research Network. Nature. 2013;497(7447):67-73. doi: 10.1038/nature12113
- Nechushkina VM, Denginina NV, Kolomiets LA, et al. Practical recommendations for the treatment of uterine cancer and uterine sarcoma. Malignant tumors: Practical recommendations RUSSCO #3s2. 2018;8:190–203. (In Russ).
- Baltrukova AN, Berlev IV, Bershtein LM. Comparative assessment of the hormonal and metabolic status of patients with endometrial cancer over the past five decades. Journal of obstetrics and women’s diseases. 2016;65(1):9-16. (In Russ). doi: 10.17816/JOWD6519-16
- Resnick KE, Hampel H, Fishel R, et al. Current and emerging trends in Lynch syndrome identification in women with endometrial cancer. Gynecol Oncol. 2009;114(1):128–34. doi: 10.1016/j.ygyno.2009.03.003
- Bokhman YaV. Rukovodstvo po onkoginekologii. Moscow: Medicine; 1989. 325 p. (In Russ).
- Van den Bosch T, Coosemans A, Morina M, et al. Screening for uterine tumors. Best practice and research. Best Pract Res Clin Obstet Gynaecol. 2012;26(2):257–66. doi: 10.1016/j.bpobgyn.2011.08.002
- Gavrish YuE, Berlev IV, Artemyeva AS. Uterine cancer in older women: what are its distinguishing characteristics? Tumors of female reproductive system. 2017;13(2):56-60. (In Russ). doi: 10.17650/1994-4098-2017-13-2-56-60
- Panici PB, Basile S, Giovanna M, et al. Secondary analyses from a randomized clinical trial: age as the key prognostic factor in endometrial carcinoma. Am J Obstet Gynecol. 2013; 210(4):363. doi: 10.1016/j.ajog.2013.12.025
- Kaprin AD, Starinsky VV, Shakhzadova AO, editors. Zlokachestvennye novoobrazovaniya v Rossii v 2020 godu (zabolevaemost’ i smertnost’). Moscow: P.A. Herzen Moscow State Research Institute; 2021. 252 p. (In Russ).
- Dinkelspiel HE, Wright JD, Lewin SN, et al. Contemporary clinical management of endometrial cancer. Obstet Gynecol Int. 2013;2013:583891. doi: 10.1155/2013/583891.
- Cusimano MC, Simpson AN, Dossa F, et al. Laparoscopic and robotic hysterectomy in endometrial cancer patients with obesity: a systematic review and meta-analysis of conversions and complications. Am J Obstet Gynecol. 2019;221(5):410-28. doi: 10.1016/j.ajog.2019.05.004
- Nevadunsky NS, Van Arsdale A, Strickler HD, et al. Obesity and age at diagnosis of endometrial cancer. Obstet Gynecol. 2014;124(2 Pt 1):300–6. doi: 10.1097/AOG.0000000000000381
- Shakirova EA, Zotova OA. The state of metabolic processes in women of reproductive age with obesity and endometrial hyperplastic processes. Fundamental and Clinical Medicine. 2016;1(2):76-81. (In Russ).
- Alberti KG, Eckel RH, Grundy SM, et al. Diabetes Federation Task Force on epidemiology and prevention. Circulation. 2009;120(16):1640–5. doi: 10.1161/CIRCULATIONAHA.109.192644
- Kishkina AYu, Kolomiets LA, Yunusova NV. Clinical variants of the metabolic syndrome in patients with endometrial cancer. Siberian journal of oncology. 2019;18(5):38–44. (In Russ). doi: 10.21294/1814-4861-2019-18-5-38-44