Assessment of disability in patients with alkaptonuria
- Authors: Kuzin A.V.1,2, Zaytseva E.M.1, Amirdzhanova V.N.3, Makarov S.A.2, Agzamov J.S.4, Ismailov K.G.5, Zar V.V.6, Dolzhenkova E.A.7, Politova N.N.8
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Affiliations:
- Russian Medical Academy of Continuous Professional Education (FSBEI FPE RMACPE)
- Federal State Budgetary Scientific Institution Research Institute of Rheumatogy named after V.A. Nasonova
- 2 Federal State Budgetary Scientific Institution Research Institute of Rheumatogy named after V.A. Nasonova
- Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia (FRCC FMBA)
- A.A. Vishnevsky Central Military Clinical Hospital № 3
- The State Budgetary Healthcare Institution of Moscow Area Moscows regional research clinical institute n.a. M.F. Vladimirskiy (MRRCI n.a. M.F. Vladimirskiy)
- Ryazan Regional Clinical Hospital
- Kirov State Medical University
- Issue: Vol 23, No 2 (2020)
- Pages: 42-45
- Section: Current problems of medical and social expertise
- URL: https://rjmseer.com/1560-9537/article/view/35167
- DOI: https://doi.org/10.17816/MSER35167
- ID: 35167
Cite item
Abstract
Background. Alkaptonuria is an orphan, autosomal recessive disease in which clinical symptoms debut in adulthood and are characterized by progressive degenerative changes in large joints (knee, hip, shoulder) and the spine, often leading to the need for joint replacement. Developing changes often lead to persistent disability.
The purpose of this study was to evaluate disability among adult patients with alkaptonuria.
Materials and methods. The study included 46 adult patients (31 m − 67.4% and 15 w − 32.6%) with a reliable diagnosis of alkaptonuria at the age of 20 to 76 years (avg age 56.83 ± 10.52). The assessment of the presence of a disability group at the time of patients’ treatment to a rheumatologist was carried out.
Results. It turned out that disability was determined in 34 (75.6%) patients, there were no signs of persistent disability in 11 patients (24.4%). Among the patients who had signs of persistent disability, most often during the survey period, group 2 disability was established (61.8%), the differences between this and other groups were statistically significant (p < 0.05). For the first time, disability in the study cohort of patients was established at the age of 31 to 59 years (the average age was 50.83 ± 5.5 years).
Conclusions. It is important to note that in the vast majority of cases, persistent disability occurs in patients who were of working age, which underscores the importance of alkaptonuria as a medical and social problem.
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About the authors
Alexander V. Kuzin
Russian Medical Academy of Continuous Professional Education (FSBEI FPE RMACPE); Federal State Budgetary Scientific Institution Research Institute of Rheumatogy named after V.A. Nasonova
Author for correspondence.
Email: alexandr.kuzin@list.ru
ORCID iD: 0000-0002-1262-932X
MD, PhD
Russian Federation, 2/1 Barrikadnaya St., 123995 Moscow; MoscowElena M. Zaytseva
Russian Medical Academy of Continuous Professional Education (FSBEI FPE RMACPE)
Email: zayele@mail.ru
ORCID iD: 0000-0001-9092-9398
MD
Russian Federation, MoscowVera N. Amirdzhanova
2 Federal State Budgetary Scientific Institution Research Institute of Rheumatogy named after V.A. Nasonova
Email: amirver@yandex.ru
ORCID iD: 0000-0001-5382-6357
MD, PhD
Russian Federation, MoscowSergey A. Makarov
Federal State Budgetary Scientific Institution Research Institute of Rheumatogy named after V.A. Nasonova
Email: ortopedniir@mail.ru
ORCID iD: 0000-0001-8563-0631
MD, PhD
Russian Federation, MoscowJahangir S. Agzamov
Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia (FRCC FMBA)
Email: dr.agzamov@gmail.com
MD, PhD
Russian Federation, MoscowKhalid G. Ismailov
A.A. Vishnevsky Central Military Clinical Hospital № 3
Email: Ismailov_endo@mail.ru
Russian Federation, Moscow
Vadim V. Zar
The State Budgetary Healthcare Institution of Moscow Area Moscows regional research clinical institute n.a. M.F. Vladimirskiy (MRRCI n.a. M.F. Vladimirskiy)
Email: Vzar@list.ru
ORCID iD: 0000-0002-4021-798X
MD, PhD
Russian Federation, MoscowElena A. Dolzhenkova
Ryazan Regional Clinical Hospital
Email: 79109012823@yandex.ru
ORCID iD: 0000-0002-4992-7953
Russian Federation, Ryazan
Natalia N. Politova
Kirov State Medical University
Email: nnpolitova@yandex.ru
MD, PhD
Russian Federation, Kirov