Development of a panel of biomarkers for differential diagnosis of multiple sclerosis

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Abstract

Demyelinating diseases are a group of heterogeneous pathologies that affect the nervous system and reduce the quality of life. One such disease is multiple sclerosis (MS), an inflammatory autoimmune neurodegenerative disease of the central nervous system (CNS). At the initial stages, MS can mimic some infectious, neoplastic, genetic, metabolic, vascular and other pathologies. Accurate differential diagnosis of this disease is important to improve the quality of life of patients and reduce possible irreversible damage to the central nervous system. In this work, we confirmed the possibility of using our previously proposed candidate panel of MS biomarkers to distinguish MS from neuromyelitis optica spectrum diseases (NMOSD) and amyotrophic lateral sclerosis (ALS). We have shown that our proposed panel (SPTAN1601-644 + PRX451-494 + PTK6301-344 + LMP1285-330) allows us to distinguish MS from ALS (AUC = 0,796) and NMOSD (AUC = 0,779).

About the authors

L. A. Ovchinnikova

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Email: yasha.l@bk.ru
Russian Federation, Moscow

S. S. Dzhelad

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Email: yasha.l@bk.ru
Russian Federation, Moscow

T. O. Simaniv

Research Center of Neurology

Email: yasha.l@bk.ru
Russian Federation, Moscow

M. N. Zakharova

Research Center of Neurology

Email: yasha.l@bk.ru
Russian Federation, Moscow

Y. A. Lomakin

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Author for correspondence.
Email: yasha.l@bk.ru
Russian Federation, Moscow

A. G. Gabibov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS; Lomonosov Moscow State University

Email: gabibov@gmail.com

Academician of the RAS

Russian Federation, Moscow; Moscow

S. N. Illarioshkin

Research Center of Neurology

Email: yasha.l@bk.ru

Academician of the RAS

Russian Federation, Moscow

References

  1. Lomakin Y.A. и др. Deconvolution of B cell receptor repertoire in multiple sclerosis patients revealed a delay in tBreg maturation. // Front. Immunol. 2022. Т. 13. С. 803229.
  2. Kuhlmann T. и др. Multiple sclerosis progression: time for a new mechanism-driven framework. // Lancet Neurol. 2023. Т. 22. № 1. С. 78–88.
  3. Ömerhoca S., Akkaş S.Y., İçen N.K. Multiple sclerosis: diagnosis and differential diagnosis. // Arch Neuropsychiatr. 2018. Т. 55. № Suppl 1. С. S1–S9.
  4. Thompson A.J. и др. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. // Lancet Neurol. 2018. Т. 17. № 2. С. 162–173.
  5. Seok J.M. и др. Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using a deep learning model. // Sci. Rep. 2023. Т. 13. № 1. С. 11625.
  6. Wingerchuk D.M. и др. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. // Neurology. 2015. Т. 85. № 2. С. 177–189.
  7. Feldman E.L. и др. Amyotrophic lateral sclerosis. // Lancet. 2022. Т. 400. № 10360. С. 1363–1380.
  8. Mazzara S. и др. CombiROC: an interactive web tool for selecting accurate marker combinations of omics data. // Sci Rep. 2017. T. 7. C. 45477.

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