Transition Metal-Free Acetylene Chemistry: Trends and Rates of Development. A Review
- Authors: Schmidt E.Y.1, Trofimov B.A.1
-
Affiliations:
- Favorsky Irkutsk Institute of Chemistry of the Siberian Branch of the Russian Academy of Sciences
- Issue: Vol 521, No 2 (2025)
- Pages: 3-14
- Section: CHEMISTRY
- URL: https://rjmseer.com/2686-9535/article/view/686882
- DOI: https://doi.org/10.31857/S2686953525020017
- EDN: https://elibrary.ru/IOWTRQ
- ID: 686882
Cite item
Abstract
Behind the modern snowballing growth of publications devoted to transition metal-catalyzed chemistry of acetylene, the works dealing with acid- and base-promoted acetylene reactions stand in the background, although acid-base catalysis, along with enzymatic one, hold a dominant place in living nature. It was acid-base catalysis that was historically first introduced into human practice, and then into research. Until now, the majority of practically important reactions involving acetylene (these are mainly Favorsky reactions: vinylation of alcohols, ethynylation of carbonyl compounds, prototropic isomerization of alkynes, rearrangement of α-haloketones) represent base-catalyzed processes. Over the last decades, transition metal-free acetylene chemistry was progressing owing to the employment of superbases and superacids for the activation of the triple carbon–carbon bond. In the present paper, using recent publications of the authors (2021), the advances in application of superbase media in the chemistry of alkynes are surveyed. Also, the usage of electron-deficient acetylenes as objects especially sensitive to the action of bases in the search for new preparative reactions with participation of the triple carbon–carbon bond is analyzed. A short period (one year) was chosen in order to clearly illustrate the dynamics and efficiency of research in this area.
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About the authors
E. Yu. Schmidt
Favorsky Irkutsk Institute of Chemistry of the Siberian Branch of the Russian Academy of Sciences
Email: boris_trofimov@irioch.irk.ru
Russian Federation, Irkutsk
B. A. Trofimov
Favorsky Irkutsk Institute of Chemistry of the Siberian Branch of the Russian Academy of Sciences
Author for correspondence.
Email: boris_trofimov@irioch.irk.ru
Academician of the RAS
Russian Federation, IrkutskReferences
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