Structural Features of Ascending Aorta Wall in Premature Born Rats

O. N. Serebryakova; Серебрякова О. Н.; V. V. Ivanova; Иванова В. В.; I. V. Milto; Мильто И. В.

doi:10.31857/S0041377123060081

Structural Features of Ascending Aorta Wall in Premature Born Rats

Authors: Serebryakova O.N.¹, Ivanova V.V.¹, Milto I.V.¹^,2
Affiliations:
1. Department of Morphology and General Pathology, Siberian State Medical University
2. Department of Molecular and Cellular Radiobiology, Seversk Biophysical Research Center, Federal Medical and Biological Agency of Russia
Issue: Vol 65, No 6 (2023)
Pages: 593-600
Section: Articles
URL: https://rjmseer.com/0041-3771/article/view/669536
DOI: https://doi.org/10.31857/S0041377123060081
EDN: https://elibrary.ru/PODDDN
ID: 669536

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription Access

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

Preterm birth has a pronounced effect on all body systems, including the cardiovascular system, which undergoes significant adaptive changes in the early postnatal period of ontogenesis. A comprehensive understanding of the consequences of preterm birth is essential to ensure early prevention, detection and treatment of long-term adverse health effects. The aim of our study was to evaluate the effect of preterm birth on the structure of the wall of the ascending aorta in preterm rats. The paper presents the results of histological and morphometric analysis of ascending aorta wall in Wistar rats born on the 21st and 21.5 days of pregnancy (the total gestation period is 22 days). In ascending aorta wall of preterm born rats, signs of elastolysis and a violation of the parallelism of the elastic fenestrated membranes are found. It has been shown that preterm birth leads to a decrease in the specific volume of elastic fibers and an increase in collagen fibers in the meddle shell of ascending aorta wall in prematurely born rats.

Keywords

aorta, preterm birth, elastin, collagen, rats

References

Аверкин Н.С., Федорова М.Г., Латынова И.В., Столяров А.П., Харитонов Е.А. 2020. Взаимосвязь между отдельными морфометрическими параметрами артериальной стенки и их зависимость от возраста. Известия высших учебных заведений. Поволжский регион. Медицинские науки. Т. 2. № 54. С. 99. (Averkin N.S., Fedorova M.G, Latynova I.V., Stolyarov A.P., Kharitonov E.A. 2020. The interrelation between the individual morphometric parameters of the arterial wall and their dependence on age. University proceedings. Volga region. Medical sciences. V. 2. P. 99.)
Arribas S.M., Hinek A., Gonzalez M.C. 2006. Elastic fibers and vascular structure in hypertension. Pharmacol. Ther. V. 111. P. 771.
Bertagnolli M., Luu T., Lewandowski A., Leeson P., Nuyt A.-M. 2016. Preterm birth and hypertension: is there a link? Curr. Hypertens. Rep. V. 18: 28. https://doi.org/10.1007/s11906-016-0637-6
Chatmethakul T., Roghair R.D. 2019. Risk of hypertension following perinatal adversity: IUGR and prematurity. J. Endocrinol. V. 242. P. T21.
Cho M.H. 2022. Hypertension in adulthood is programmed during the perinatal period. Clin. Exp. Pediatr. V. 65. P. 494.
Concannon J., Dockery P., Black A., Sultan S., Hynes N., McHugh P.E., Moerman K.M., McGarry J.P. 2020. Quantification of the regional bioarchitecture in the human aorta. J. Anat. V. 236. P. 142.
de Jong F., Monuteaux M.C., van Elburg R.M., Gillman M.W., Belfort M.B. 2012. Systematic review and meta-analysis of preterm birth and later systolic blood pressure. Hypertension. V. 59. P. 226.
Hovi P., Vohr B., Ment L.R. 2016. Blood pressure in young adults born at very low birth weight: adults born preterm international collaboration. Hypertension. V. 68. P. 880.
Huyard F., Yzydorczyk C., Castro M.M., Cloutier A., Bertagnolli M., Sartelet H., Germain N., Comte B., Schulz R., DeBlois D., Nuyt A.M. 2014. Remodeling of aorta extracellular matrix as a result of transient high oxygen exposure in newborn rats: implication for arterial rigidity and hypertension risk. PLoS One. V. 9. e92287.
Lawn J., Ohuma E., Bradley E. 2023. Small babies, big risks: global estimates of prevalence and mortality for vulnerable newborns to accelerate change and improve counting. Lancet. V. 401. P. 1707.
Liefke J., Steding-Ehrenborg K., Sjöberg P., Ryd D., Morsing E., Arheden H., Ley D., Hedström E. 2023. Higher blood pressure in adolescent boys after very preterm birth and fetal growth restriction. Pediatr. Res. V. 93. P. 2019.
Liyanage L., Musto L., Budgeon C., Rutty G., Biggs M., Saratzis A., Vorp D.A., Vavourakis V., Bown M., Tsamis A. 2022. Multimodal structural analysis of the human aorta: from valve to bifurcation. Eur. J. Vasc. Endovasc. Surg. V. 63. P. 721.
Martyn C.N., Greenwald S.E. 1997. Impaired synthesis of elastin in walls of aorta and large conduit arteries during early development as an initiating event in pathogenesis of systemic hypertension. Lancet. V. 350. P. 953.
Nuyt A.M., Lavoie J., Mohamed I., Paquette K., Luu T.M. 2017. Adult consequences of extremely preterm birth: cardiovascular and metabolic diseases risk factors, mechanisms, and prevention avenues. Clin. Perinatol. V. 44. P. 315.
O’Rourke M.F., Staessen J.A., Vlachopoulos C., Duprez D., Plante G.E. 2002. Clinical applications of arterial stiffness; definitions and reference values. Am. J. Hypertens. V. 15. P. 426.
Picut C.A., Ziejewski M.K., Stanislaus D. 2018. Comparative aspects of pre- and postnatal development of the male reproductive system. Birth Defects Res. V. 110. P. 190.
Rossi P., Tauzin L., Marchand E., Boussuges A., Gaudart J., Frances Y. 2011. Respective roles of preterm birth and fetal growth restriction in blood pressure and arterial stiffness in adolescence. J. Adolesc. Health. V. 48. P. 520.
Sokolis D.P., Krithais E.P., Giagini A.T., Lampropoulos K.M., Papadodima S.A., Iliopoulos D.C. 2012. Biomechanical response of ascending aortic aneurysms: association with structural remodeling. Comput. Methods Biomech. Biomed. Engin. V. 15. P. 231.
Toyono M., Ito T., Harada K., Tamura M., Takada G. 1999. Morphological adaptation of the cardiovascular system in fetal rats during late gestation. Tohoku J. Exp. Med. V. 188. P. 299.
Tsamis A., Krawiec J.T., Vorp D.A. 2013. Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review. J. R. Soc. Interface. V. 10. e20121004.